CAB39
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.{{cite web | title = Entrez Gene: CAB39 calcium binding protein 39| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51719}}
The protein encoded by this gene associates with STK11 (Serine/Threonine Kinase 11) and STRAD (STE20-Related ADaptor protein).{{cite journal | vauthors = Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR | title = MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm | journal = EMBO J. | volume = 22 | issue = 19 | pages = 5102–14 |date=October 2003 | pmid = 14517248 | pmc = 204473 | doi = 10.1093/emboj/cdg490 }} CAB39 enhances formation of STK11/STRAD complexes and stimulates STK11 catalytic activity. CAB39 may function as a scaffolding component of the STK11/STRAD complex and regulates STK11 activity and cellular localization.
References
{{reflist}}
External links
- {{UCSC gene info|CAB39}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Baas AF, Smit L, Clevers H |title=LKB1 tumor suppressor protein: PARtaker in cell polarity |journal=Trends Cell Biol. |volume=14 |issue= 6 |pages= 312–9 |year= 2004 |pmid= 15183188 |doi= 10.1016/j.tcb.2004.04.001 }}
- {{cite journal | vauthors=Hawley SA, Davison M, Woods A |title=Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27879–87 |year= 1996 |pmid= 8910387 |doi=10.1074/jbc.271.44.27879 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Lai CH, Chou CY, Ch'ang LY |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=10.1101/gr.10.5.703 | pmc=310876 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Boudeau J, Baas AF, Deak M |title=MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm |journal=EMBO J. |volume=22 |issue= 19 |pages= 5102–14 |year= 2003 |pmid= 14517248 |doi= 10.1093/emboj/cdg490 | pmc=204473 |display-authors=etal}}
- {{cite journal | vauthors=Brajenovic M, Joberty G, Küster B |title=Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12804–11 |year= 2004 |pmid= 14676191 |doi= 10.1074/jbc.M312171200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Milburn CC, Boudeau J, Deak M |title=Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 2 |pages= 193–200 |year= 2004 |pmid= 14730349 |doi= 10.1038/nsmb716 |s2cid=18401688 |display-authors=etal}}
- {{cite journal | vauthors=Lizcano JM, Göransson O, Toth R |title=LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 |journal=EMBO J. |volume=23 |issue= 4 |pages= 833–43 |year= 2005 |pmid= 14976552 |doi= 10.1038/sj.emboj.7600110 | pmc=381014 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Boudeau J, Scott JW, Resta N |title=Analysis of the LKB1-STRAD-MO25 complex |journal=J. Cell Sci. |volume=117 |issue= Pt 26 |pages= 6365–75 |year= 2005 |pmid= 15561763 |doi= 10.1242/jcs.01571 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
{{refend}}
{{PDB Gallery|geneid=51719}}
{{gene-2-stub}}