CACNA1B

{{Short description|Protein-coding gene in humans}}

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{{Infobox_gene}}

The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene.{{cite web | title = Entrez Gene: CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=774 }}{{cite journal | vauthors = Diriong S, Lory P, Williams ME, Ellis SB, Harpold MM, Taviaux S | title = Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits | journal = Genomics | volume = 30 | issue = 3 | pages = 605–609 | date = December 1995 | pmid = 8825650 | doi = 10.1006/geno.1995.1284 }}{{cite journal | vauthors = Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J | title = International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 411–425 | date = December 2005 | pmid = 16382099 | doi = 10.1124/pr.57.4.5 | s2cid = 10386627 }} The α1B protein, together with β and α2δ subunits forms N-type calcium channel (Cav2.2 channel).{{cite journal | vauthors = Heyes S, Pratt WS, Rees E, Dahimene S, Ferron L, Owen MJ, Dolphin AC | title = Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders | journal = Progress in Neurobiology | volume = 134 | pages = 36–54 | date = November 2015 | pmid = 26386135 | pmc = 4658333 | doi = 10.1016/j.pneurobio.2015.09.002 }} It is a R-type calcium channel.{{Citation needed|date=March 2024}}

References

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Further reading

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  • {{cite journal | vauthors = Mould J, Yasuda T, Schroeder CI, Beedle AM, Doering CJ, Zamponi GW, Adams DJ, Lewis RJ | title = The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels | journal = The Journal of Biological Chemistry | volume = 279 | issue = 33 | pages = 34705–34714 | date = August 2004 | pmid = 15166237 | doi = 10.1074/jbc.M310848200 | doi-access = free }}
  • {{cite journal | vauthors = Park SY, Park YT, Kim KE, Rhee MC, Cho HJ, Kim DS | title = A direct repeat of N-type Ca2+ channel alpha1B gene functions as a negative regulatory element in HeLa cells | journal = Molecules and Cells | volume = 13 | issue = 2 | pages = 341–346 | date = April 2002 | pmid = 12018859 | doi = 10.1016/S1016-8478(23)15043-6 | doi-access = free }}
  • {{cite journal | vauthors = Calabrese B, Tabarean IV, Juranka P, Morris CE | title = Mechanosensitivity of N-type calcium channel currents | journal = Biophysical Journal | volume = 83 | issue = 5 | pages = 2560–2574 | date = November 2002 | pmid = 12414690 | pmc = 1302342 | doi = 10.1016/S0006-3495(02)75267-3 | bibcode = 2002BpJ....83.2560C }}
  • {{cite journal | vauthors = Moskvina V, Craddock N, Holmans P, Nikolov I, Pahwa JS, Green E, Owen MJ, O'Donovan MC | title = Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk | journal = Molecular Psychiatry | volume = 14 | issue = 3 | pages = 252–260 | date = March 2009 | pmid = 19065143 | pmc = 3970088 | doi = 10.1038/mp.2008.133 }}
  • {{cite journal | vauthors = Castiglioni AJ, Raingo J, Lipscombe D | title = Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels | journal = The Journal of Physiology | volume = 576 | issue = Pt 1 | pages = 119–134 | date = October 2006 | pmid = 16857708 | pmc = 1995641 | doi = 10.1113/jphysiol.2006.115030 }}
  • {{cite journal | vauthors = Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J | title = International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 411–425 | date = December 2005 | pmid = 16382099 | doi = 10.1124/pr.57.4.5 | s2cid = 10386627 }}
  • {{cite journal | vauthors = Yokoyama CT, Myers SJ, Fu J, Mockus SM, Scheuer T, Catterall WA | title = Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site | journal = Molecular and Cellular Neurosciences | volume = 28 | issue = 1 | pages = 1–17 | date = January 2005 | pmid = 15607937 | doi = 10.1016/j.mcn.2004.08.019 | s2cid = 38370138 }}
  • {{cite journal | vauthors = Maeno-Hikichi Y, Chang S, Matsumura K, Lai M, Lin H, Nakagawa N, Kuroda S, Zhang JF | title = A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels | journal = Nature Neuroscience | volume = 6 | issue = 5 | pages = 468–475 | date = May 2003 | pmid = 12665800 | doi = 10.1038/nn1041 | s2cid = 19964052 }}
  • {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–648 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
  • {{cite journal | vauthors = Li D, Wang F, Lai M, Chen Y, Zhang JF | title = A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C | journal = The Journal of Neuroscience | volume = 25 | issue = 8 | pages = 1914–1923 | date = February 2005 | pmid = 15728831 | pmc = 6726054 | doi = 10.1523/JNEUROSCI.4790-04.2005 }}
  • {{cite journal | vauthors = Butcher AJ, Leroy J, Richards MW, Pratt WS, Dolphin AC | title = The importance of occupancy rather than affinity of CaV(beta) subunits for the calcium channel I-II linker in relation to calcium channel function | journal = The Journal of Physiology | volume = 574 | issue = Pt 2 | pages = 387–398 | date = July 2006 | pmid = 16627564 | pmc = 1817768 | doi = 10.1113/jphysiol.2006.109744 }}
  • {{cite journal | vauthors = Stotz SC, Barr W, McRory JE, Chen L, Jarvis SE, Zamponi GW | title = Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit | journal = The Journal of Biological Chemistry | volume = 279 | issue = 5 | pages = 3793–3800 | date = January 2004 | pmid = 14602720 | doi = 10.1074/jbc.M308991200 | doi-access = free }}
  • {{cite journal | vauthors = Maximov A, Bezprozvanny I | title = Synaptic targeting of N-type calcium channels in hippocampal neurons | journal = The Journal of Neuroscience | volume = 22 | issue = 16 | pages = 6939–6952 | date = August 2002 | pmid = 12177192 | pmc = 3307533 | doi = 10.1523/JNEUROSCI.22-16-06939.2002 }}
  • {{cite journal | vauthors = Peng S, Hajela RK, Atchison WD | title = Characteristics of block by Pb2+ of function of human neuronal L-, N-, and R-type Ca2+ channels transiently expressed in human embryonic kidney 293 cells | journal = Molecular Pharmacology | volume = 62 | issue = 6 | pages = 1418–1430 | date = December 2002 | pmid = 12435810 | doi = 10.1124/mol.62.6.1418 }}
  • {{cite journal | vauthors = Murakami M, Fleischmann B, De Felipe C, Freichel M, Trost C, Ludwig A, Wissenbach U, Schwegler H, Hofmann F, Hescheler J, Flockerzi V, Cavalié A | title = Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40342–40351 | date = October 2002 | pmid = 12161429 | doi = 10.1074/jbc.M203425200 | hdl-access = free | doi-access = free | hdl = 10261/310195 }}
  • {{cite journal | vauthors = Vitko I, Shcheglovitov A, Baumgart JP, Arias-Olguín II, Murbartián J, Arias JM, Perez-Reyes E | title = Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity | journal = PLOS ONE | volume = 3 | issue = 10 | pages = e3560 | year = 2008 | pmid = 18958281 | pmc = 2570331 | doi = 10.1371/journal.pone.0003560 | editor1-last = Schwartz | doi-access = free | bibcode = 2008PLoSO...3.3560V | editor1-first = Arnold }}
  • {{cite journal | vauthors = Coppola T, Magnin-Luthi S, Perret-Menoud V, Gattesco S, Schiavo G, Regazzi R | title = Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 32756–32762 | date = August 2001 | pmid = 11438518 | doi = 10.1074/jbc.M100929200 | doi-access = free }}
  • {{cite journal | vauthors = Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, Santos R, Schadt EE, Stoughton R, Shoemaker DD | title = Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays | journal = Science | volume = 302 | issue = 5653 | pages = 2141–2144 | date = December 2003 | pmid = 14684825 | doi = 10.1126/science.1090100 | s2cid = 10007258 | bibcode = 2003Sci...302.2141J }}
  • {{cite journal | vauthors = Agler HL, Evans J, Tay LH, Anderson MJ, Colecraft HM, Yue DT | title = G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels | journal = Neuron | volume = 46 | issue = 6 | pages = 891–904 | date = June 2005 | pmid = 15953418 | doi = 10.1016/j.neuron.2005.05.011 | s2cid = 16963916 | doi-access = free }}

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