CACNA2D1

Alpha-2/delta proteins are believed to be the molecular target of the gabapentinoids gabapentin and pregabalin, which are used to treat epilepsy and neuropathic pain.{{cite journal | vauthors = Rogawski MA, Bazil CW | title = New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels | journal = Current Neurology and Neuroscience Reports | volume = 8 | issue = 4 | pages = 345–352 | date = July 2008 | pmid = 18590620 | pmc = 2587091 | doi = 10.1007/s11910-008-0053-7 }}{{Cite journal | vauthors = Patel R, Dickenson AH | title = Mechanisms of the gabapentinoids andα2δ-1 calcium channel subunit in neuropathic pain | journal = Pharmacology Research & Perspectives | volume = 4 | issue = 2 | pages = e00205 | date = 2016-04-01 | pmid = 27069626 | pmc = 4804325 | doi = 10.1002/prp2.205 | language = en | issn = 2052-1707 }}{{Cite journal | vauthors = Patel R, Bauer CS, Nieto-Rostro M, Margas W, Ferron L, Chaggar K, Crews K, Ramirez JD, Bennett DL, Schwartz A, Dickenson AH, Dolphin AC | title = α2δ-1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage | journal = The Journal of Neuroscience | volume = 33 | issue = 42 | pages = 16412–16426 | date = 2013-10-16 | pmid = 24133248 | pmc = 3797367 | doi = 10.1523/jneurosci.1026-13.2013 }} Only alpha-2/delta subtypes 1 and 2 (but not 3 and 4) are substrates for gabapentinoid drug binding.

• Voltage-dependent calcium channel
• Gabapentinoid drugs

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• {{MeshName|CACNA2D1+protein,+human}}
• {{UCSC gene info|CACNA2D1}}

{{NLM content}}

{{Ion channels|g1}}

Category:Ion channels

{{membrane-protein-stub}}