CACNA2D2
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.{{cite web | title = Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9254}}
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
CACNA2D2 containing channels are blocked by amiodarone.{{cite web |url=https://www.drugbank.ca/drugs/DB01118|publisher=Drugbank|title=Amiodarone|access-date=2019-05-28}}
See also
References
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Further reading
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- {{cite journal | vauthors=Donato R, Page KM, Koch D |title=The ducky2J mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression |journal=J. Neurosci. |volume=26 |issue= 48 |pages= 12576–86 |year= 2006 |pmid= 17135419 |doi= 10.1523/JNEUROSCI.3080-06.2006 | pmc=1797058 |display-authors=etal}}
- {{cite journal | vauthors=Carboni GL, Gao B, Nishizaki M |title=CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity |journal=Oncogene |volume=22 |issue= 4 |pages= 615–26 |year= 2003 |pmid= 12555074 |doi= 10.1038/sj.onc.1206134 |pmc=3484891|display-authors=etal}}
- {{cite journal | vauthors=Honorio S, Gordon K, MacCartney D |title=Identification of a single nucleotide polymorphism in the human alpha 2 delta 2 calcium channel subunit gene |journal=Mol. Cell. Probes |volume=15 |issue= 6 |pages= 391–3 |year= 2002 |pmid= 11851383 |doi= 10.1006/mcpr.2001.0382 |display-authors=etal}}
- {{cite journal | vauthors=Angeloni D, Duh FM, Wei MF |s2cid=38006979 |title=A G-to-A single nucleotide polymorphism in intron 2 of the human CACNA2D2 gene that maps at 3p21.3 |journal=Mol. Cell. Probes |volume=15 |issue= 2 |pages= 125–7 |year= 2001 |pmid= 11292331 |doi= 10.1006/mcpr.2000.0341 |display-authors=etal|hdl=11382/301708 |hdl-access=free }}
- {{cite journal | vauthors=Lerman MI, Minna JD |title=The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium |journal=Cancer Res. |volume=60 |issue= 21 |pages= 6116–33 |year= 2000 |pmid= 11085536 }}
- {{cite journal | vauthors=Gao B, Sekido Y, Maximov A |title=Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2) |journal=J. Biol. Chem. |volume=275 |issue= 16 |pages= 12237–42 |year= 2000 |pmid= 10766861 |doi=10.1074/jbc.275.16.12237 |pmc=3484885|display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Hobom M, Dai S, Marais E |title=Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit |journal=Eur. J. Neurosci. |volume=12 |issue= 4 |pages= 1217–26 |year= 2000 |pmid= 10762351 |doi=10.1046/j.1460-9568.2000.01009.x |s2cid=82569498 |display-authors=etal}}
- {{cite journal | vauthors=Nagase T, Ishikawa K, Miyajima N |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=10.1093/dnares/5.1.31 |display-authors=etal|doi-access=free }}
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External links
- {{MeshName|CACNA2D2+protein,+human}}
- {{UCSC gene info|CACNA2D2}}
{{NLM content}}
{{Ion channels|g1}}