CADPS
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.{{cite journal | vauthors = Walent JH, Porter BW, Martin TF | title = A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells | journal = Cell | volume = 70 | issue = 5 | pages = 765–75 |date=Oct 1992 | pmid = 1516133 | doi =10.1016/0092-8674(92)90310-9 | s2cid = 29122392 }}{{cite web | title = Entrez Gene: CADPS Ca2+-dependent secretion activator| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8618}}
CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.
References
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External links
- {{UCSC gene info|CADPS}}
- {{UCSC gene info|CAPS}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Nishizaki T, Walent JH, Kowalchyk JA, Martin TF |title=A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C. |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 23972–81 |year= 1992 |doi=10.1016/S0021-9258(18)35932-5 |pmid= 1429734 |doi-access=free }}
- {{cite journal | vauthors=Ann K, Kowalchyk JA, Loyet KM, Martin TF |title=Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 19637–40 |year= 1997 |pmid= 9289490 |doi=10.1074/jbc.272.32.19637 |doi-access=free }}
- {{cite journal | vauthors=Loyet KM, Kowalchyk JA, Chaudhary A |title=Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 8337–43 |year= 1998 |pmid= 9525942 |doi=10.1074/jbc.273.14.8337 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Berwin B, Floor E, Martin TF |title=CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis. |journal=Neuron |volume=21 |issue= 1 |pages= 137–45 |year= 1998 |pmid= 9697858 |doi=10.1016/S0896-6273(00)80521-8 |doi-access=free }}
- {{cite journal | vauthors=Hirosawa M, Nagase T, Ishikawa K |title=Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=6 |issue= 5 |pages= 329–36 |year= 2000 |pmid= 10574461 |doi=10.1093/dnares/6.5.329 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Cisternas FA, Vincent JB, Scherer SW, Ray PN |title=Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. |journal=Genomics |volume=81 |issue= 3 |pages= 279–91 |year= 2003 |pmid= 12659812 |doi=10.1016/S0888-7543(02)00040-X }}
- {{cite journal | vauthors=Speidel D, Varoqueaux F, Enk C |title=A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52802–9 |year= 2004 |pmid= 14530279 |doi= 10.1074/jbc.M304727200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Binda AV, Kabbani N, Levenson R |title=Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS). |journal=Biochem. Pharmacol. |volume=69 |issue= 10 |pages= 1451–61 |year= 2005 |pmid= 15857609 |doi= 10.1016/j.bcp.2005.02.015 }}
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