CAMK1

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.{{cite journal | vauthors = Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR | title = Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase | journal = EMBO J | volume = 14 | issue = 15 | pages = 3679–86 |date=Sep 1995 | pmid = 7641687 | pmc = 394442 | doi = 10.1002/j.1460-2075.1995.tb00037.x}}

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.{{cite web | title = Entrez Gene: CAMK1 calcium/calmodulin-dependent protein kinase I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8536}}

References

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{{cite journal | vauthors=Yokokura H, Picciotto MR, Nairn AC, Hidaka H |title=The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains |journal=J. Biol. Chem. |volume=270 |issue= 40 |pages= 23851–9 |year= 1995 |pmid= 7559563 |doi=10.1074/jbc.270.40.23851 |doi-access=free }}
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{{cite journal | vauthors=Chin D, Winkler KE, Means AR |title=Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31235–40 |year= 1998 |pmid= 9395448 |doi=10.1074/jbc.272.50.31235 |doi-access=free }}
{{cite journal | vauthors=Hsu LS, Tsou AP, Chi CW |title=Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase |journal=J. Biomed. Sci. |volume=5 |issue= 2 |pages= 141–9 |year= 1998 |pmid= 9662074 |doi= 10.1007/bf02258368|display-authors=etal}}
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{{cite journal | vauthors=Komeima K, Hayashi Y, Naito Y, Watanabe Y |title=Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28139–43 |year= 2000 |pmid= 10874031 |doi= 10.1074/jbc.M003198200 |doi-access= free }}
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{{cite journal | vauthors=McKinsey TA, Zhang CL, Olson EN |title=Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14400–5 |year= 2001 |pmid= 11114197 |doi= 10.1073/pnas.260501497 | pmc=18930 |bibcode=2000PNAS...9714400M |doi-access=free }}
{{cite journal | vauthors=Hsu LS, Chen GD, Lee LS |title=Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31113–23 |year= 2001 |pmid= 11395482 |doi= 10.1074/jbc.M011720200 |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Condon JC, Pezzi V, Drummond BM |title=Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase |journal=Endocrinology |volume=143 |issue= 9 |pages= 3651–7 |year= 2002 |pmid= 12193581 |doi=10.1210/en.2001-211359 |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Sakurada K, Kato H, Nagumo H |title=Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45473–9 |year= 2003 |pmid= 12237306 |doi= 10.1074/jbc.M206673200 |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Clapperton JA, Martin SR, Smerdon SJ |title=Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism |journal=Biochemistry |volume=41 |issue= 50 |pages= 14669–79 |year= 2003 |pmid= 12475216 |doi=10.1021/bi026660t |display-authors=etal}}
{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Izmailova E, Bertley FM, Huang Q |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 |s2cid=26145639 |display-authors=etal}}

External links

{{UCSC gene info|CAMK1}}

Category:EC 2.7.11

CAMK1

References

Further reading

External links