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CAMK2D

{{Short description|Protein-coding gene in humans}}

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{{Infobox gene}}

Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene.{{cite web | title = Entrez Gene: CAMK2D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=817 }}

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca2+/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date. Distinct isoforms of this chain have different expression patterns.

References

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Further reading

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  • {{cite journal | vauthors = Hook SS, Means AR | title = Ca2+/CaM-dependent kinases: from activation to function | journal = Annual Review of Pharmacology and Toxicology | date = 2001 | volume = 41 | issue = 1 | pages = 471–505 | pmid = 11264466 | doi = 10.1146/annurev.pharmtox.41.1.471 }}
  • {{cite journal | vauthors = Yamamoto H | title = [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions] | journal = Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme | volume = 47 | issue = 3 | pages = 241–247 | date = Mar 2002 | pmid = 11889801 }}
  • {{cite journal | vauthors = de Groot RP, den Hertog J, Vandenheede JR | title = Multiple and cooperative phosphorylation events regulate the CREM activator function | journal = The EMBO Journal | volume = 12 | issue = 10 | pages = 3903–3911 | date = Oct 1993 | pmid = 8404858 | pmc = 413673 | doi = 10.1002/j.1460-2075.1993.tb06068.x }}
  • {{cite journal | vauthors = Tombes RM, Krystal GW | title = Identification of novel human tumor cell-specific CaMK-II variants | journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | volume = 1355 | issue = 3 | pages = 281–292 | date = Mar 1997 | pmid = 9060999 | doi = 10.1016/S0167-4889(96)00141-3 | doi-access = free }}
  • {{cite journal | vauthors = Moyers JS, Bilan PJ, Zhu J, Kahn CR | title = Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II | journal = Journal of Biological Chemistry | volume = 272 | issue = 18 | pages = 11832–11839 | date = May 1997 | pmid = 9115241 | doi = 10.1074/jbc.272.18.11832 | doi-access = free }}
  • {{cite journal | vauthors = Möhlig M, Wolter S, Mayer P | title = Insulinoma cells contain an isoform of Ca2+/calmodulin-dependent protein kinase II delta associated with insulin secretion vesicles | journal = Endocrinology | volume = 138 | issue = 6 | pages = 2577–2584 | date = Jun 1997 | pmid = 9165051 | doi = 10.1210/endo.138.6.5168 | doi-access = free }}
  • {{cite journal | vauthors = Bauch A, Campbell KS, Reth M | title = Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta | journal = European Journal of Immunology | volume = 28 | issue = 7 | pages = 2167–2177 | date = Jul 1998 | pmid = 9692886 | doi = 10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO;2-L | doi-access = free }}
  • {{cite journal | vauthors = ((Sanger Center)), ((Genome Sequencing Center)) | title = Toward a complete human genome sequence | journal = Genome Research | volume = 8 | issue = 11 | pages = 1097–1108 | date = Nov 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 | doi-access = free }}
  • {{cite journal | vauthors = Hoch B, Meyer R, Hetzer R | title = Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium | journal = Circulation Research | volume = 84 | issue = 6 | pages = 713–721 | date = Apr 1999 | pmid = 10189359 | doi = 10.1161/01.res.84.6.713 | doi-access = free }}
  • {{cite journal | vauthors = Tombes RM, Mikkelsen RB, Jarvis WD, Grant S | title = Downregulation of delta CaM kinase II in human tumor cells | journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | volume = 1452 | issue = 1 | pages = 1–11 | date = Oct 1999 | pmid = 10525155 | doi = 10.1016/S0167-4889(99)00113-5 | doi-access = free }}
  • {{cite journal | vauthors = Rochlitz H, Voigt A, Lankat-Buttgereit B | title = Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells | journal = Diabetologia | volume = 43 | issue = 4 | pages = 465–473 | date = Apr 2000 | pmid = 10819240 | doi = 10.1007/s001250051330 | doi-access = free }}
  • {{cite journal | vauthors = Inagaki N, Nishizawa M, Arimura N | title = Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons | journal = Journal of Biological Chemistry | volume = 275 | issue = 35 | pages = 27165–27171 | date = Sep 2000 | pmid = 10852918 | doi = 10.1074/jbc.M003751200 | doi-access = free }}
  • {{cite journal | vauthors = Nair JS, DaFonseca CJ, Tjernberg A | title = Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 9 | pages = 5971–5976 | date = Apr 2002 | pmid = 11972023 | pmc = 122886 | doi = 10.1073/pnas.052159099 | bibcode = 2002PNAS...99.5971N | doi-access = free }}
  • {{cite journal | vauthors = Mishra-Gorur K, Singer HA, Castellot JJ | title = The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II | journal = Journal of Biological Chemistry | volume = 277 | issue = 37 | pages = 33537–33540 | date = Sep 2002 | pmid = 12145273 | doi = 10.1074/jbc.C200342200 | doi-access = free }}
  • {{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 26 | pages = 16899–16903 | date = Dec 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 | bibcode = 2002PNAS...9916899M | doi-access = free }}
  • {{cite journal | vauthors = Ota T, Suzuki Y, Nishikawa T | title = Complete sequencing and characterization of 21,243 full-length human cDNAs | journal = Nature Genetics | volume = 36 | issue = 1 | pages = 40–45 | date = Jan 2004 | pmid = 14702039 | doi = 10.1038/ng1285 | doi-access = free }}
  • {{cite journal | vauthors = Gaertner TR, Kolodziej SJ, Wang D | title = Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II | journal = Journal of Biological Chemistry | volume = 279 | issue = 13 | pages = 12484–12494 | date = Mar 2004 | pmid = 14722083 | doi = 10.1074/jbc.M313597200 | doi-access = free }}
  • {{cite journal | vauthors = Ballif BA, Villén J, Beausoleil SA | title = Phosphoproteomic analysis of the developing mouse brain | journal = Molecular & Cellular Proteomics | volume = 3 | issue = 11 | pages = 1093–1101 | date = Nov 2004 | pmid = 15345747 | doi = 10.1074/mcp.M400085-MCP200 | doi-access = free }}

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External links

  • {{UCSC gene info|CAMK2D}}

{{Serine/threonine-specific protein kinases}}

{{Enzymes}}

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Category:EC 2.7.11

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