CAPN10

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The typical calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. The heterodimer interface is predominantly found between domain IV and the small subunit, which is also a calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It therefore cannot heterodimerize with the small subunit. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.{{cite web | title = Entrez Gene: CAPN10 calpain 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11132}}

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• {{cite journal | vauthors=Sorimachi H, Ishiura S, Suzuki K |title=Structure and physiological function of calpains. |journal=Biochem. J. |volume=328 |issue= 3|pages= 721–32 |year= 1998 |pmid= 9396712 |doi= 10.1042/bj3280721| pmc=1218978 }}
• {{cite journal | author=Cox NJ |title=Linkage of calpain 10 to type 2 diabetes: the biological rationale |journal=Diabetes |volume=53 |pages= S19–25 |year= 2004 |pmid= 14749261 |doi= 10.2337/diabetes.53.2007.s19| author2=Hayes MG | author3=Roe CA | display-authors=3 | last4=Tsuchiya | first4=T | last5=Bell | first5=GI |issue=Suppl 1 |doi-access=free}}
• {{cite journal | vauthors=Turner MD, Cassell PG, Hitman GA |title=Calpain-10: from genome search to function |journal=Diabetes Metab. Res. Rev. |volume=21 |issue= 6 |pages= 505–14 |year= 2006 |pmid= 16028216 |doi= 10.1002/dmrr.578 |s2cid=39651682 |doi-access=free }}
• {{cite journal | author=Horikawa Y |title=Calpain-10 (NIDDM1) as a Susceptibility Gene for Common Type 2 Diabetes |journal=Endocr. J. |volume=53 |issue= 5 |pages= 567–76 |year= 2007 |pmid= 16873988 |doi=10.1507/endocrj.KR-70 |doi-access=free }}
• {{cite journal | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=10.1093/dnares/8.2.85 | author2=Nakayama M | author3=Nakajima D | display-authors=3 | last4=Kikuno | first4=R | last5=Ohara | first5=O |doi-access=free}}
• {{cite journal | author=Ma H |title=Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28525–31 |year= 2001 |pmid= 11375982 |doi= 10.1074/jbc.M100603200 | author2=Fukiage C | author3=Kim YH | display-authors=3 | last4=Duncan | first4=MK | last5=Reed | first5=NA | last6=Shih | first6=M | last7=Azuma | first7=M | last8=Shearer | first8=TR | doi-access=free }}
• {{cite journal | author=Evans JC |title=Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom |journal=Am. J. Hum. Genet. |volume=69 |issue= 3 |pages= 544–52 |year= 2001 |pmid= 11481585 |doi=10.1086/323315 | pmc=1235484 | author2=Frayling TM | author3=Cassell PG | display-authors=3 | last4=Saker | first4=Philip J. | last5=Hitman | first5=Graham A. | last6=Walker | first6=Mark | last7=Levy | first7=Jonathan C. | last8=o’Rahilly | first8=Stephen | last9=Rao | first9=Pamidighantam V. Subba }}
• {{cite journal | author=Tsai HJ |title=Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association |journal=Am. J. Hum. Genet. |volume=69 |issue= 6 |pages= 1236–44 |year= 2002 |pmid= 11704924 |doi=10.1086/324646 | pmc=1235535 | author2=Sun G | author3=Weeks DE | display-authors=3 | last4=Kaushal | first4=Ritesh | last5=Wolujewicz | first5=Michael | last6=McGarvey | first6=Stephen T. | last7=Tufa | first7=Joseph | last8=Viali | first8=Satupaitea | last9=Deka | first9=Ranjan }}
• {{cite journal | vauthors=Woollard JR, Rothschild MF |title=Assignment of the porcine calpain-10 gene (CAPN10) to chromosome 15q23-26 |journal=Anim. Genet. |volume=32 |issue= 6 |pages= 393 |year= 2002 |pmid= 11736815 |doi=10.1046/j.1365-2052.2001.0781d.x }}
• {{cite journal | author=Xiang K |title=[The impact of calpain-10 gene combined-SNP variation on type 2 diabetes mellitus and its related metabolic traits] |journal=Zhonghua Yi Xue Yi Chuan Xue Za Zhi |volume=18 |issue= 6 |pages= 426–30 |year= 2002 |pmid= 11774208 | author2=Fang Q | author3=Zheng T | display-authors=3 | last4=Jia | first4=W | last5=Wang | first5=Y | last6=Zhang | first6=R | last7=Li | first7=J | last8=Shen | first8=K }}
• {{cite journal | author=Elbein SC |title=Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 2 |pages= 650–4 |year= 2002 |pmid= 11836299 |doi=10.1210/jcem.87.2.8210 | author2=Chu W | author3=Ren Q | display-authors=3 | last4=Hemphill | first4=C | last5=Schay | first5=J | last6=Cox | first6=NJ | last7=Hanis | first7=CL | last8=Hasstedt | first8=SJ | doi-access=free }}
• {{cite journal | author=Daimon M |title=Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese |journal=Diabetes Res. Clin. Pract. |volume=56 |issue= 2 |pages= 147–52 |year= 2002 |pmid= 11891023 |doi=10.1016/S0168-8227(01)00372-2 | author2=Oizumi T | author3=Saitoh T | display-authors=3 | last4=Kameda | first4=W | last5=Yamaguchi | first5=H | last6=Ohnuma | first6=H | last7=Igarashi | first7=M | last8=Manaka | first8=H | last9=Kato | first9=T }}
• {{cite journal | author=Fullerton SM |title=Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus |journal=Am. J. Hum. Genet. |volume=70 |issue= 5 |pages= 1096–106 |year= 2002 |pmid= 11891618 |doi=10.1086/339930 | pmc=447588 | author2=Bartoszewicz A | author3=Ybazeta G | display-authors=3 | last4=Horikawa | first4=Yukio | last5=Bell | first5=Graeme I. | last6=Kidd | first6=Kenneth K. | last7=Cox | first7=Nancy J. | last8=Hudson | first8=Richard R. | last9=Di Rienzo | first9=Anna }}
• {{cite journal | author=Hoffstedt J |title=Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells |journal=Diabetologia |volume=45 |issue= 2 |pages= 276–82 |year= 2002 |pmid= 11935160 |doi= 10.1007/s00125-001-0732-2 | author2=Rydén M | author3=Löfgren P | display-authors=3 | last4=Orho-Melander | first4=M. | last5=Groop | first5=L. | last6=Arner | first6=P. | doi-access=free}}
• {{cite journal | author=Malecki MT |title=Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population |journal=Eur. J. Endocrinol. |volume=146 |issue= 5 |pages= 695–9 |year= 2002 |pmid= 11980626 |doi=10.1530/eje.0.1460695 | author2=Moczulski DK | author3=Klupa T | display-authors=3 | last4=Wanic | first4=K | last5=Cyganek | first5=K | last6=Frey | first6=J | last7=Sieradzki | first7=J | doi-access=free }}
• {{cite journal | author=Sun HX |title=Single nucleotide polymorphisms in CAPN10 gene of Chinese people and its correlation with type 2 diabetes mellitus in Han people of northern China |journal=Biomed. Environ. Sci. |volume=15 |issue= 1 |pages= 75–82 |year= 2002 |pmid= 12046551 | author2=Zhang KX | author3=Du WN | display-authors=3 | last4=Shi | first4=JX | last5=Jiang | first5=ZW | last6=Sun | first6=H | last7=Zuo | first7=J | last8=Huang | first8=W | last9=Chen | first9=Z }}
• {{cite journal | author=Haddad L |title=Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 6 |pages= 2606–10 |year= 2002 |pmid= 12050223 |doi=10.1210/jcem.87.6.8608 | author2=Evans JC | author3=Gharani N | display-authors=3 | last4=Robertson | first4=C | last5=Rush | first5=K | last6=Wiltshire | first6=S | last7=Frayling | first7=TM | last8=Wilkin | first8=TJ | last9=Demaine | first9=A | doi-access=free }}

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• The MEROPS online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C02.018 C02.018] {{Webarchive|url=https://web.archive.org/web/20080228151526/http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C02.018 |date=2008-02-28 }}
• {{UCSC gene info|CAPN10}}

{{Cysteine proteases}}

{{gene-2-stub}}