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CAPN5

{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.{{cite journal | vauthors = Matena K, Boehm T, Dear N | title = Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily | journal = Genomics | volume = 48 | issue = 1 | pages = 117–20 |date=Apr 1998 | pmid = 9503024 | doi =10.1006/geno.1997.5133 }}{{cite journal | vauthors = Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M | title = Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene | journal = Biochem Biophys Res Commun | volume = 239 | issue = 3 | pages = 845–50 |date=Dec 1997 | pmid = 9367857 | doi = 10.1006/bbrc.1997.7571 }}{{cite web | title = Entrez Gene: CAPN5 calpain 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=726}}

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.

References

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Further reading

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  • {{cite journal | vauthors=Vanderklish PW, Bahr BA |title=The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states |journal=International Journal of Experimental Pathology |volume=81 |issue= 5 |pages= 323–39 |year= 2001 |pmid= 11168679 |doi=10.1111/j.1365-2613.2000.00169.x |pmc=2517738}}
  • {{cite journal | vauthors=Sato K, Kawashima S |title=Calpain function in the modulation of signal transduction molecules |journal=Biol. Chem. |volume=382 |issue= 5 |pages= 743–51 |year= 2002 |pmid= 11517927 |doi=10.1515/BC.2001.090 |s2cid=882390 }}
  • {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal | vauthors=Dear N, Matena K, Vingron M, Boehm T |title=A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution |journal=Genomics |volume=45 |issue= 1 |pages= 175–84 |year= 1997 |pmid= 9339374 |doi= 10.1006/geno.1997.4870 }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Waghray A, Wang DS, McKinsey D |title=Molecular cloning and characterization of rat and human calpain-5 |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 1 |pages= 46–51 |year= 2004 |pmid= 15464980 |doi= 10.1016/j.bbrc.2004.09.012 |display-authors=etal}}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=González A, Sáez ME, Aragón MJ |title=Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome |journal=Hum. Reprod. |volume=21 |issue= 4 |pages= 943–51 |year= 2006 |pmid= 16396936 |doi= 10.1093/humrep/dei443 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Sáez ME, Martínez-Larrad MT, Ramírez-Lorca R |title=Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels |journal=BMC Med. Genet. |volume=8|pages= 1 |year= 2007 |pmid= 17227582 |doi= 10.1186/1471-2350-8-1 | pmc=1783645 |display-authors=etal |doi-access=free }}

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External links

  • The MEROPS online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C02.011 C02.011] {{Webarchive|url=https://web.archive.org/web/20050308125635/http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C02.011 |date=2005-03-08 }}
  • {{UCSC gene info|CAPN5}}
  • {{UCSC gene info|HTRA3}}

{{Cysteine proteases}}

{{gene-11-stub}}