CASP8AP2
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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CASP8-associated protein 2 is a protein, that in humans is encoded by the CASP8AP2 gene.{{cite journal | vauthors = Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S | title = The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis | journal = Nature | volume = 398 | issue = 6730 | pages = 777–85 | date = Jun 1999 | pmid = 10235259 | doi = 10.1038/19709 | bibcode = 1999Natur.398..777I | s2cid = 2792230 }}{{cite journal | vauthors = Milovic-Holm K, Krieghoff E, Jensen K, Will H, Hofmann TG | title = FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies | journal = EMBO J. | volume = 26 | issue = 2 | pages = 391–401 | date = Jan 2007 | pmid = 17245429 | pmc = 1783462 | doi = 10.1038/sj.emboj.7601504 }}{{cite journal | vauthors = Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V | title = FLASH is an essential component of Cajal bodies | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 40 | pages = 14802–7 | date = Oct 2006 | pmid = 17003126 | pmc = 1578500 | doi = 10.1073/pnas.0604225103 | bibcode = 2006PNAS..10314802B | doi-access = free }}{{cite web | title = Entrez Gene: CASP8AP2 CASP8 associated protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9994}}
Function
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Researches of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex, that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.
Interactions
CASP8AP2 has been shown to interact with TRAF2.{{cite journal | vauthors = Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK | title = FLASH coordinates NF-kappa B activity via TRAF2 | journal = J. Biol. Chem. | volume = 276 | issue = 27 | pages = 25073–7 | date = Jul 2001 | pmid = 11340079 | doi = 10.1074/jbc.M102941200 | doi-access = free }}
References
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Further reading
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- {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 | doi-access = free }}
- {{cite journal | vauthors = Koonin EV, Aravind L, Hofmann K, Tschopp J, Dixit VM | title = Apoptosis. Searching for FLASH domains | journal = Nature | volume = 401 | issue = 6754 | pages = 662; discussion 662–3 | year = 1999 | pmid = 10537104 | doi = 10.1038/44317 | bibcode = 1999Natur.401Q.662K | s2cid = 4390408 | url = https://zenodo.org/record/1233239 | doi-access = free }}
- {{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 1 | pages = 65–73 | year = 2000 | pmid = 10718198 | doi = 10.1093/dnares/7.1.65 | doi-access = free }}
- {{cite journal | vauthors = Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK | title = FLASH coordinates NF-kappa B activity via TRAF2 | journal = J. Biol. Chem. | volume = 276 | issue = 27 | pages = 25073–7 | year = 2001 | pmid = 11340079 | doi = 10.1074/jbc.M102941200 | doi-access = free }}
- {{cite journal | vauthors = Kino T, Chrousos GP | title = Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators | journal = J. Biol. Chem. | volume = 278 | issue = 5 | pages = 3023–9 | year = 2003 | pmid = 12477726 | doi = 10.1074/jbc.M209234200 | doi-access = free }}
- {{cite journal | vauthors = Jun JI, Chung CW, Lee HJ, Pyo JO, Lee KN, Kim NS, Kim YS, Yoo HS, Lee TH, Kim E, Jung YK | title = Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway | journal = Oncogene | volume = 24 | issue = 4 | pages = 688–96 | year = 2005 | pmid = 15592525 | doi = 10.1038/sj.onc.1208186 | doi-access = | s2cid = 12720899 }}
- {{cite journal | vauthors = Kino T, Ichijo T, Chrousos GP | title = FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors | journal = J. Steroid Biochem. Mol. Biol. | volume = 92 | issue = 5 | pages = 357–63 | year = 2004 | pmid = 15698540 | doi = 10.1016/j.jsbmb.2004.09.003 | s2cid = 41799122 | url = https://zenodo.org/record/1259189 }}
- {{cite journal | vauthors = Flotho C, Coustan-Smith E, Pei D, Iwamoto S, Song G, Cheng C, Pui CH, Downing JR, Campana D | title = Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2 | journal = Blood | volume = 108 | issue = 3 | pages = 1050–7 | year = 2006 | pmid = 16627760 | pmc = 1895863 | doi = 10.1182/blood-2006-01-0322 }}
- {{cite journal | vauthors = Barcaroli D, Bongiorno-Borbone L, Terrinoni A, Hofmann TG, Rossi M, Knight RA, Matera AG, Melino G, De Laurenzi V | title = FLASH is required for histone transcription and S-phase progression | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 40 | pages = 14808–12 | year = 2006 | pmid = 17003125 | pmc = 1578501 | doi = 10.1073/pnas.0604227103 | bibcode = 2006PNAS..10314808B | doi-access = free }}
- {{cite journal | vauthors = Jeong EG, Lee SH, Lee HW, Soung YH, Yoo NJ, Lee SH | title = Immunohistochemical and mutational analysis of FLASH in gastric carcinomas | journal = APMIS | volume = 115 | issue = 8 | pages = 900–5 | year = 2007 | pmid = 17696945 | doi = 10.1111/j.1600-0463.2007.apm_706.x | s2cid = 25074994 }}
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External links
- {{UCSC genome browser|CASP8AP2}}
- {{UCSC gene details|CASP8AP2}}
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