CAZy

{{Short description|Enzyme database}}

{{About|the database|the community in the United States|Cazy, West Virginia}}

{{Infobox biodatabase

|title = CAZy

|logo =File:Database.png

|description = carbohydrate-active enzymes database

|scope =

|organism =

|center = AFMB, French National Centre for Scientific Research

|laboratory = Glycogenomics group

|author =

|citation = Lombard & al. (2014)

|released =

|standard =

|format =

|url = http://www.cazy.org/

|download =

|webservice =

|sql =

|sparql =

|webapp = http://research.ahv.dk/cazy

http://mothra.ornl.gov/cgi-bin/cat/cat.cgi

http://csbl.bmb.uga.edu/dbCAN/

|standalone =

|license =

|versioning =

|frequency =

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|version=

}}

CAZy is a database of Carbohydrate-Active enZYmes (CAZymes).{{cite journal |vauthors=Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, Henrissat B | title = The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics | journal = Nucleic Acids Res. | volume = 37 | issue = Database issue | pages = D233–8 |date=January 2009 | pmid = 18838391 | pmc = 2686590 | doi = 10.1093/nar/gkn663 }} The database contains a classification and associated information about enzymes involved in the synthesis, metabolism, and recognition of complex carbohydrates, i.e. disaccharides, oligosaccharides, polysaccharides, and glycoconjugates. Included in the database are families of glycoside hydrolases, glycosyltransferases, polysaccharide lyases, carbohydrate esterases,{{Cite journal|last1=Nakamura|first1=Aline M.|last2=Nascimento|first2=Alessandro S.|last3=Polikarpov|first3=Igor|date=2017|title=Structural diversity of carbohydrate esterases|journal=Biotechnology Research and Innovation|volume=1|issue=1|pages=35–51|doi=10.1016/j.biori.2017.02.001|doi-access=free}} and non-catalytic carbohydrate-binding modules.{{Cite journal|last1=Armenta|first1=Silvia|last2=Moreno-Mendieta|first2=Silvia|last3=Sánchez-Cuapio|first3=Zaira|last4=Sánchez|first4=Sergio|last5=Rodríguez-Sanoja|first5=Romina|date=2017|title=Advances in molecular engineering of carbohydrate-binding modules|journal=Proteins|volume=85|issue=9|pages=1602–1617|doi=10.1002/prot.25327|pmid=28547780|s2cid=26493197}} The CAZy database also includes a classification of Auxiliary Activity redox enzymes involved in the breakdown of lignocellulose.{{cite journal |vauthors=Levasseur A, Drula E, Lombard V, Coutinho PM, Henrissat B | title = Expansion of the enzymatic repertoire of the CAZy database to integrate auxiliary redox enzymes | journal = Biotechnol Biofuels | volume = 6 | issue = 1 | pages = 41 |date=March 2013 | pmid = 23514094 | pmc = 3620520 | doi = 10.1186/1754-6834-6-41 | doi-access = free }}

CAZy was established in 1999 in order to provide online and constantly updated access to the protein sequence-based family classification of CAZymes,{{cite journal|last1=Lombard|first1=V.|last2=Golaconda Ramulu|first2=H.|last3=Drula|first3=E.|last4=Coutinho|first4=P. M.|last5=Henrissat|first5=B.|title=The carbohydrate-active enzymes database (CAZy) in 2013|journal=Nucleic Acids Research|date=2014|volume=42|issue=D1|pages=D490–D495|doi=10.1093/nar/gkt1178|pmid=24270786|pmc=3965031}} which was originally developed in early 1990s to classify the glycoside hydrolases. New entries are added shortly after they appear in the daily releases of GenBank. The rapid evolution of high-throughput DNA sequencing has resulted in the continuing exponential growth of the CAZy database, which now covers hundreds of thousands of sequences.Current statistics are available on each [http://www.cazy.org/Glycoside-Hydrolases.html Glycoside Hydrolase], [http://www.cazy.org/GlycosylTransferases.html Glycosyltransferase], [http://www.cazy.org/Polysaccharide-Lyases.html Polysaccharide Lyase], [http://www.cazy.org/Carbohydrate-Esterases.html Carbohydrate Esterase], [http://www.cazy.org/Auxiliary-Activities.html Auxiliary-Activity], and [http://www.cazy.org/Carbohydrate-Binding-Modules.html Carbohydrate-Binding Module] section page. CAZy continues to be curated and developed by the Glycogenomics group at AFMB, a research centre affiliated with the French National Centre for Scientific Research and Aix-Marseille University.{{cite web|url=http://www.cazy.org/About-Us.html|title=About|website=CAZy.org|accessdate=3 September 2014}}{{cite web|title=AFMB UMR 7257 - UMR7257 : CNRS - AIX MARSEILLE UNIV|url=http://www.afmb.univ-mrs.fr/?lang=en|website=www.afmb.univ-mrs.fr|accessdate=3 September 2014}}

The CAZy database is coupled with [http://www.cazypedia.org/ CAZypedia], which was launched in 2007 as a research community-driven, wiki-based encyclopedia of CAZymes.{{cite journal |vauthors = ((CAZypedia Consortium)) | title = Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes | journal = Glycobiology | volume = 28 | issue = 1 | pages = 3–8 |date = 2018 | pmid = 29040563 | doi = 10.1093/glycob/cwx089 | doi-access = free | hdl = 21.11116/0000-0003-B7EB-6 | hdl-access = free }}