CBLC
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.{{cite journal | vauthors = Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S | title = cbl-3: a new mammalian cbl family protein | journal = Oncogene | volume = 18 | issue = 22 | pages = 3365–75 |date=Jun 1999 | pmid = 10362357 | doi = 10.1038/sj.onc.1202753 | doi-access = | s2cid = 28195948 }}{{cite journal | vauthors = Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T | title = Molecular cloning and characterization of a novel cbl-family gene, cbl-c | journal = Gene | volume = 239 | issue = 1 | pages = 145–54 |date=Dec 1999 | pmid = 10571044 | doi =10.1016/S0378-1119(99)00356-X }}{{cite web | title = Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23624}}
CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]
Interactions
CBLC has been shown to interact with FYN{{cite journal |last=Kim |first=M |author2=Tezuka T|author3=Suziki Y|author4=Sugano S|author5=Hirai M|author6=Yamamoto T |date=Oct 1999 |title=Molecular cloning and characterization of a novel cbl-family gene, cbl-c |journal=Gene |volume=239 |issue=1 |pages=145–54 |location = NETHERLANDS| issn = 0378-1119| pmid = 10571044 |doi=10.1016/S0378-1119(99)00356-X }} and Epidermal growth factor receptor.{{cite journal |last=Keane |first=M M |author2=Ettenberg S A|author3=Nau M M|author4=Banerjee P|author5=Cuello M|author6=Penninger J|author7=Lipkowitz S |date=Jun 1999 |title=cbl-3: a new mammalian cbl family protein |journal=Oncogene |volume=18 |issue=22 |pages=3365–75 |location = ENGLAND| issn = 0950-9232| pmid = 10362357 |doi = 10.1038/sj.onc.1202753 |doi-access= |s2cid=28195948 }}
References
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External links
- {{UCSC gene info|CBLC}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Ollendorff V, Mattei M, Fournier E |title=A third human CBL gene is on chromosome 19 |journal=Int. J. Oncol. |volume=13 |issue= 6 |pages= 1159–61 |year= 1999 |pmid= 9824625 |doi= 10.3892/ijo.13.6.1159|display-authors=etal}}
- {{cite journal | vauthors=Irby RB, Mao W, Coppola D |title=Activating SRC mutation in a subset of advanced human colon cancers |journal=Nat. Genet. |volume=21 |issue= 2 |pages= 187–90 |year= 1999 |pmid= 9988270 |doi= 10.1038/5971 |s2cid=27129630 |display-authors=etal}}
- {{cite journal | vauthors=Ettenberg SA, Keane MM, Nau MM |title=Cbl-b inhibits epidermal growth factor receptor signaling |journal=Oncogene |volume=18 |issue= 10 |pages= 1855–66 |year= 1999 |pmid= 10086340 |doi= 10.1038/sj.onc.1202499 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Loreto MP, Berry DM, McGlade CJ |title=Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4241–55 |year= 2002 |pmid= 12024036 |doi=10.1128/MCB.22.12.4241-4255.2002 | pmc=133880 }}
- {{cite journal | vauthors=Szymkiewicz I, Kowanetz K, Soubeyran P |title=CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39666–72 |year= 2002 |pmid= 12177062 |doi= 10.1074/jbc.M205535200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Courbard JR, Fiore F, Adélaïde J |title=Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45267–75 |year= 2003 |pmid= 12226085 |doi= 10.1074/jbc.M206460200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Wong ES, Fong CW, Lim J |title=Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling |journal=EMBO J. |volume=21 |issue= 18 |pages= 4796–808 |year= 2002 |pmid= 12234920 |doi=10.1093/emboj/cdf493 | pmc=126289 |display-authors=etal}}
- {{cite journal | vauthors=Taher TE, Tjin EP, Beuling EA |title=C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination |journal=J. Immunol. |volume=169 |issue= 7 |pages= 3793–800 |year= 2002 |pmid= 12244174 |doi= 10.4049/jimmunol.169.7.3793|display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Nau MM, Lipkowitz S |title=Comparative genomic organization of the cbl genes |journal=Gene |volume=308 |pages= 103–13 |year= 2003 |pmid= 12711395 |doi=10.1016/S0378-1119(03)00471-2 }}
- {{cite journal | vauthors=Kim M, Tezuka T, Tanaka K, Yamamoto T |title=Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation |journal=Oncogene |volume=23 |issue= 9 |pages= 1645–55 |year= 2004 |pmid= 14661060 |doi= 10.1038/sj.onc.1207298 |doi-access= |s2cid=24925646 }}
- {{cite journal | vauthors=Kassenbrock CK, Anderson SM |title=Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28017–27 |year= 2004 |pmid= 15117950 |doi= 10.1074/jbc.M404114200 |doi-access= free }}
- {{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal|bibcode=2004PNAS..10112130B |doi-access=free }}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R |s2cid=4427026 }}
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