CCDC11
{{Short description|Protein-coding gene in humans}}
Coiled-Coil Domain Containing 11, also known as CCDC11 is a protein, that is encoded by CCDC11 gene located at chromosome 18 in humans.{{cite web | title = coiled-coil domain containing 11| url =https://www.genecards.org/cgi-bin/carddisp.pl?gene=CCDC11| accessdate = 25 Feb 2012}}
Overview
The CCDC11 gene is located on chromosome 18q21.1 and is made of 39303 BP.{{cite web | title = GeneCards | url = https://www.genecards.org| accessdate = 25 Feb 2012}} The CCDC11 protein is made of 514 amino acids and has a mass of 61835 Da. Its aliases include coiled-coil domain containing protein 11, FLJ32743, OTTHUMP00000163503.
Homology
CCDC has orthologs all the way back to betaproteobacteria which is a class of Proteobacteria. The following table represents a small selection of orthologs found using searches in BLAST and BLAT. This is by no means a comprehensive list; however, it shows the diversity of species that CCDC11 is found.
| class="wikitable"
! Species ! Organism Common Name ! NCBI Accession ! Length (AAs) ! Sequence Identity ! Sequence Similarity | |||||
| Homo sapiens | Human | [https://www.ncbi.nlm.nih.gov/protein/NP_659457 NP_659457] | 514 | 100% | 100% |
| Pan troglodytes | Chimpanzee | [https://www.ncbi.nlm.nih.gov/protein/XP_523923.3 XP_523923.3] | 514 | 99% | 99% |
| Callithrix jacchus | Marmoset | [https://www.ncbi.nlm.nih.gov/protein/XP_002757278.1 XP_002757278.1] | 514 | 92% | 95% |
| Ailuropoda melanoleuca | Panda | [https://www.ncbi.nlm.nih.gov/protein/XP_002930158.1 XP_002939158.1] | 514 | 83% | 91% |
| Canis familiaris | Dog | [https://www.ncbi.nlm.nih.gov/protein/XP_547689.3 XP_547689.3] | 514 | 82% | 91% |
| Bos taurus | Cow | [https://www.ncbi.nlm.nih.gov/protein/XP_002697813.1 XP_002697813.1] | 514 | 81% | 91% |
| Loxodonata africana | Elephant | [https://www.ncbi.nlm.nih.gov/protein/XP_003406348.1 XP_003406348.1] | 514 | 80% | 91% |
| Rattus norvegicus | Rat | [https://www.ncbi.nlm.nih.gov/protein/XP_001053914.2 XP_001053914.2] | 514 | 71% | 87% |
| Mus musculus | Mouse | [https://www.ncbi.nlm.nih.gov/protein/NP_083224.2 NP_083224.2] | 514 | 70% | 87% |
| Ornithorhynchus anatinus | Platypus | [https://www.ncbi.nlm.nih.gov/protein/XP_001509001.2 XP_001509001.2] | 465 | 49% | 72% |
| Monodelphis domestica | Opossum | [https://www.ncbi.nlm.nih.gov/protein/XP_001372850.2 XP_001372850.2] | 507 | 47% | 70% |
| Xenopus tropicalis | Frog | [https://www.ncbi.nlm.nih.gov/protein/NP_001120281.1 NP_001120281.1] | 516 | 39% | 65% |
| Anolis carolinensis | Lizard | [https://www.ncbi.nlm.nih.gov/protein/XP_003227331.1 XP_003227331.1] | 514 | 37% | 62% |
| Nematostella vectensis | Sea anemone | [https://www.ncbi.nlm.nih.gov/protein/XP_001628275.1 XP_001628275.1] | 440 | 36% | 58% |
| Branchiostoma floridae | Lancelet | [https://www.ncbi.nlm.nih.gov/protein/XP_002609924.1 XP_002609924.1] | 528 | 35% | 61% |
| Trichoplax adhaerens | Trichoplax | [https://www.ncbi.nlm.nih.gov/protein/XP_002111027.1 XP_002111027.1] | 514 | 33% | 60% |
| Danio rerio | Zebra fish | [https://www.ncbi.nlm.nih.gov/protein/NP_001038595 NP_001038595.2] | 519 | 32% | 58% |
| Amphimedon queenslandica | Sponge | [https://www.ncbi.nlm.nih.gov/protein/XP_003389146 XP_003389146.1] | 513 | 31% | 60% |
Gene neighborhood
The below image from NCBI shows the gene neighborhood of CCDC11 on chromosome 18. CCDC11 has methyl-CPG binding domain protein 1, MBD1, upstream and myosin VB3, MYO5B, downstream. All CCDC11, MBD1 and MYO5B are oriented negatively. Note the close proximity between MBD1 and CCDC11.
Predicted Post-Translational Modification
Tools on the ExPASy Proteomics site{{cite web| title = ExPASy Proteomics tools| url = http://ca.expasy.org/tools/#ptm| accessdate = 15 Apr 2012| archive-date = 10 August 2011| archive-url = https://web.archive.org/web/20110810093220/http://ca.expasy.org/tools#ptm| url-status = dead}} predict the following post-translational modifications:
| class="wikitable"
! Tool ! Predicted Modification | ||||
| YinOYang{{cite web | title = YinOYang| url = http://www.cbs.dtu.dk/services/YinOYang/| accessdate = 15 Apr 2012}} | O-β-GlcNAc | T239, S510 | T239 | T239, S509, T510 |
| NetPhos{{cite web | title = NetPhos| url = http://www.cbs.dtu.dk/services/NetPhos/| accessdate = 15 Apr 2012}} | phosphorylation | T8, T17, S43, S53, S56, S57, Y112, T134, S170, S240, S425, S461 | T17, S43, S53, S56, S107, Y112, S114, S170, T284, S287, S492 | T17, S56, T64, S107, T112, T122, T325, S442, S482, S507 |
One tool on the ExPASy, {{proper name|iPSORT}}, showed no signal peptide;however, it indicated CCDC11 to be mitochondrial. Another tool on the ExPASy, SOSUI, indicated the protein to be a soluble protein.