CCL13

{{Short description|Mammalian protein found in Homo sapiens}}

{{protein

| Name = chemokine (C-C motif) ligand 13

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| HGNCid = 10611

| Symbol = CCL13

| AltSymbols = SCYA13, MCP-4, NCC-1, SCYL1, CKb10

| EntrezGene = 6357

| OMIM = 601391

| RefSeq = NM_005408

| UniProt = Q99616

| PDB =

| ECnumber =

| Chromosome = 17

| Arm = q

| Band = 11.2

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Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family. Its gene is located on human chromosome 17 within a large cluster of other CC chemokines.Garcia-Zepeda EA, et al.. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol. 1996;157:5613–5626Naruse et al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996, 34(2):236-40. CCL13 induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5.Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905. Activity of this chemokine has been implicated in allergic reactions such as asthma.Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32. CCL13 can be induced by the inflammatory cytokines interleukin-1 and TNF-α.