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CCL19

{{Short description|Mammalian protein found in Homo sapiens}}

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{{Infobox_gene}}

Chemokine (C-C motif) ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene.{{cite journal | vauthors = Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O | title = Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7 | journal = J Biol Chem | volume = 272 | issue = 21 | pages = 13803–9 |date=Jul 1997 | pmid = 9153236 | doi =10.1074/jbc.272.21.13803 | doi-access = free }}{{cite web | title = Entrez Gene: CCL19 chemokine (C-C motif) ligand 19| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6363}}

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.

Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen.{{cite journal | vauthors = Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O | title = Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7 | journal = J. Biol. Chem. | volume = 272 | issue = 21 | pages = 13803–9 | year = 1997 | pmid = 9153236 | doi = 10.1074/jbc.272.21.13803 | doi-access = free }} The gene for CCL19 is located on human chromosome 9.{{cite journal | vauthors = Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A | title = Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta | journal = J. Immunol. | volume = 158 | issue = 3 | pages = 1033–6 | year = 1997 | doi = 10.4049/jimmunol.158.3.1033 | pmid = 9013939 | s2cid = 39291729 | url = http://www.jimmunol.org/cgi/content/abstract/158/3/1033 | doi-access = free | url-access = subscription }} This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells,{{cite journal | vauthors = Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ | title = The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes | journal = Cell | volume = 103 | issue = 5 | pages = 757–68 | year = 2000 | pmid = 11114332 | doi = 10.1016/S0092-8674(00)00179-3 | s2cid = 15592251 | doi-access = free }}{{cite journal | vauthors = Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG | title = Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position | journal = Nature | volume = 416 | issue = 6876 | pages = 94–9 | year = 2002 | pmid = 11882900 | doi = 10.1038/416094a | bibcode = 2002Natur.416...94R | s2cid = 4403093 }} CCR7+ central-memory T-Cells.{{cite journal | vauthors = Bromley SK, Thomas SY, Luster AD | title = Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics | journal = Nat. Immunol. | volume = 6 | issue = 9 | pages = 895–901 | year = 2005 | pmid = 16116469 | doi = 10.1038/ni1240 | s2cid = 443455 }}

References

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Further reading

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  • {{cite journal | vauthors=Weber C, Koenen RR |title=Fine-tuning leukocyte responses: towards a chemokine 'interactome'. |journal=Trends Immunol. |volume=27 |issue= 6 |pages= 268–73 |year= 2006 |pmid= 16678487 |doi= 10.1016/j.it.2006.04.002 }}
  • {{cite journal | author=Rossi DL |title=Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta |journal=J. Immunol. |volume=158 |issue= 3 |pages= 1033–6 |year= 1997 |pmid= 9013939 | author2=Vicari AP | author3=Franz-Bacon K | display-authors=3 | last4=McClanahan | first4=TK | last5=Zlotnik | first5=A |doi=10.4049/jimmunol.158.3.1033 |s2cid=39291729 |doi-access=free }}
  • {{cite journal | author=Nagira M |title=Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13 |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19518–24 |year= 1997 |pmid= 9235955 |doi=10.1074/jbc.272.31.19518 | author2=Imai T | author3=Hieshima K | display-authors=3 | last4=Kusuda | first4=J | last5=Ridanpää | first5=M | last6=Takagi | first6=S | last7=Nishimura | first7=M | last8=Kakizaki | first8=M | last9=Nomiyama | first9=H | doi-access=free }}
  • {{cite journal | author=Kim CH |title=CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells |journal=J. Immunol. |volume=160 |issue= 5 |pages= 2418–24 |year= 1998 |pmid= 9498785 | author2=Pelus LM | author3=White JR | display-authors=3 | last4=Applebaum | first4=E | last5=Johanson | first5=K | last6=Broxmeyer | first6=HE |doi=10.4049/jimmunol.160.5.2418 |s2cid=82739698 |doi-access=free}}
  • {{cite journal | author=Yanagihara S |title=EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation |journal=J. Immunol. |volume=161 |issue= 6 |pages= 3096–102 |year= 1998 |pmid= 9743376 | author2=Komura E | author3=Nagafune J | display-authors=3 | last4=Watarai | first4=H | last5=Yamaguchi | first5=Y |doi=10.4049/jimmunol.161.6.3096 |s2cid=26084149 |doi-access=free }}
  • {{cite journal | author=Gosling J |title=Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK |journal=J. Immunol. |volume=164 |issue= 6 |pages= 2851–6 |year= 2000 |pmid= 10706668 |doi= 10.4049/jimmunol.164.6.2851| author2=Dairaghi DJ | author3=Wang Y | display-authors=3 | last4=Hanley | first4=M | last5=Talbot | first5=D | last6=Miao | first6=Z | last7=Schall | first7=TJ | doi-access=free }}
  • {{cite journal | author=Annunziato F |title=Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection |journal=J. Immunol. |volume=165 |issue= 1 |pages= 238–46 |year= 2000 |pmid= 10861057 |doi= 10.4049/jimmunol.165.1.238| author2=Romagnani P | author3=Cosmi L | display-authors=3 | last4=Beltrame | first4=C | last5=Steiner | first5=BH | last6=Lazzeri | first6=E | last7=Raport | first7=CJ | last8=Galli | first8=G | last9=Manetti | first9=R | doi-access=free }}
  • {{cite journal | author=Ueno T |title=Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus |journal=Immunity |volume=16 |issue= 2 |pages= 205–18 |year= 2002 |pmid= 11869682 |doi=10.1016/S1074-7613(02)00267-4 | author2=Hara K | author3=Willis MS | display-authors=3 | last4=Malin | first4=Mark A. | last5=Höpken | first5=Uta E. | last6=Gray | first6=Daniel H.D. | last7=Matsushima | first7=Kouji | last8=Lipp | first8=Martin | last9=Springer | first9=Timothy A. | doi-access=free }}
  • {{cite journal | vauthors=Phillips R, Ager A |title=Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells |journal=Eur. J. Immunol. |volume=32 |issue= 3 |pages= 837–47 |year= 2002 |pmid= 11870628 |doi=10.1002/1521-4141(200203)32:3<837::AID-IMMU837>3.0.CO;2-Q |s2cid=41323072 |doi-access=free }}
  • {{cite journal | vauthors=Till KJ, Lin K, Zuzel M, Cawley JC |title=The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes |journal=Blood |volume=99 |issue= 8 |pages= 2977–84 |year= 2002 |pmid= 11929789 |doi=10.1182/blood.V99.8.2977 |doi-access=free }}
  • {{cite journal | vauthors=Townson JR, Nibbs RJ |title=Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR |journal=Eur. J. Immunol. |volume=32 |issue= 5 |pages= 1230–41 |year= 2002 |pmid= 11981810 |doi= 10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L |s2cid=21911348 }}
  • {{cite journal | vauthors=Page G, Lebecque S, Miossec P |title=Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium |journal=J. Immunol. |volume=168 |issue= 10 |pages= 5333–41 |year= 2002 |pmid= 11994492 |doi= 10.4049/jimmunol.168.10.5333|doi-access=free }}
  • {{cite journal | author=Katou F |title=Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin |journal=J. Pathol. |volume=199 |issue= 1 |pages= 98–106 |year= 2003 |pmid= 12474232 |doi= 10.1002/path.1255 | author2=Ohtani H | author3=Nakayama T | display-authors=3 | last4=Nagura | first4=Hiroshi | last5=Yoshie | first5=Osamu | last6=Motegi | first6=Katsutoshi |s2cid=25424987 }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Scandella E |title=CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2 |journal=Blood |volume=103 |issue= 5 |pages= 1595–601 |year= 2004 |pmid= 14592837 |doi= 10.1182/blood-2003-05-1643 | author2=Men Y | author3=Legler DF | display-authors=3 | last4=Gillessen | first4=S | last5=Prikler | first5=L | last6=Ludewig | first6=B | last7=Groettrup | first7=M | doi-access=free }}
  • {{cite journal | author=Corcione A |title=CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells |journal=Clin. Cancer Res. |volume=10 |issue= 3 |pages= 964–71 |year= 2004 |pmid= 14871974 |doi=10.1158/1078-0432.CCR-1182-3 | author2=Arduino N | author3=Ferretti E | display-authors=3 | last4=Raffaghello | first4=L | last5=Roncella | first5=S | last6=Rossi | first6=D | last7=Fedeli | first7=F | last8=Ottonello | first8=L | last9=Trentin | first9=L |s2cid=9041635 | doi-access= }}
  • {{cite journal | author=Daikoku N |title=Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle |journal=Fertil. Steril. |volume=81 |pages= 876–81 |year= 2004 |pmid= 15019823 |doi= 10.1016/j.fertnstert.2003.09.036 | author2=Kitaya K | author3=Nakayama T | display-authors=3 | last4=Fushiki | first4=Shinji | last5=Honjo | first5=Hideo |issue=Suppl 1 |doi-access=free}}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Paoletti S |title=A rich chemokine environment strongly enhances leukocyte migration and activities |journal=Blood |volume=105 |issue= 9 |pages= 3405–12 |year= 2005 |pmid= 15546958 |doi= 10.1182/blood-2004-04-1648 | author2=Petkovic V | author3=Sebastiani S | display-authors=3 | last4=Danelon | first4=MG | last5=Uguccioni | first5=M | last6=Gerber | first6=BO | doi-access=free}}

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External links

  • {{UCSC gene info|CCL19}}

{{Chemokines}}

{{Chemokine receptor modulators}}

Category:Cytokines