CCL24
{{Short description|Mammalian protein found in Homo sapiens}}
{{infobox protein
| Name = chemokine (C-C motif) ligand 24
| caption =
| image =
| width =
| HGNCid = 10623
| Symbol = CCL24
| AltSymbols = SCYA24, Ckb-6, MPIF-2, eotaxin-2
| EntrezGene = 6369
| OMIM = 602495
| RefSeq = NM_002991
| UniProt = O00175
| PDB = 1EIG
| ECnumber =
| Chromosome = 7
| Arm = q
| Band = 11.23
| LocusSupplementaryData =
}}
Chemokine (C-C motif) ligand 24 (CCL24) also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2) is a protein that in humans is encoded by the CCL24 gene. This gene is located on human chromosome 7.{{cite journal | vauthors = Hillier LW, Fulton RS, Fulton LA | title = The DNA sequence of human chromosome 7 | journal = Nature | volume = 424 | issue = 6945 | pages = 157–64 |date=July 2003 | pmid = 12853948 | doi = 10.1038/nature01782 | bibcode = 2003Natur.424..157H |display-authors=etal| doi-access = free }}
Function
CCL24 is a small cytokine belonging to the CC chemokine family. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils.{{cite journal | vauthors = White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM | title = Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils | journal = J. Leukoc. Biol. | volume = 62 | issue = 5 | pages = 667–75 |date=November 1997 | pmid = 9365122 | doi = 10.1002/jlb.62.5.667| s2cid = 12197497 | doi-access = free }} This chemokine is also strongly chemotactic for resting T lymphocytes and slightly chemotactic for neutrophils.{{cite journal | vauthors = Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G | title = Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors | journal = J. Exp. Med. | volume = 185 | issue = 7 | pages = 1163–72 |date=April 1997 | pmid = 9104803 | pmc = 2196270 | doi = 10.1084/jem.185.7.1163}}
Clinical significance
Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma.{{cite journal | vauthors = Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS | title = Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease | journal = Allergy | volume = 65| issue = 3| pages = 338–346|date=October 2009 | pmid = 19796209 | doi = 10.1111/j.1398-9995.2009.02158.x | s2cid = 205404242 | doi-access = free }}