CCL26

{{Short description|Mammalian protein found in Homo sapiens}}

{{protein

| Name = chemokine (C-C motif) ligand 26

| caption =

| image =

| width =

| HGNCid = 10625

| Symbol = CCL26

| AltSymbols = SCYA26, MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1

| EntrezGene = 10344

| OMIM = 604697

| RefSeq = NM_006072

| UniProt = Q9Y258

| PDB = 1G2T

| ECnumber =

| Chromosome = 7

| Arm = q

| Band = 11.2

| LocusSupplementaryData =

}}

Chemokine (C-C motif) ligand 26 (CCL26) is a small cytokine belonging to the CC chemokine family that is also called Eotaxin-3, Macrophage inflammatory protein 4-alpha

(MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4.Shinkai et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J. Immunol. 163:1602-1610, 1999.Guo et al. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. Genomics 58:313-317, 1999. CCL26 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3.Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999. This gene for chemokine is located on human chromosome 7.Hillier et al. The DNA sequence of human chromosome 7. Nature 424:157-164, 2003.