CCL3

CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes{{cite journal | vauthors = Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A | title = Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties | journal = The Journal of Experimental Medicine | volume = 167 | issue = 2 | pages = 570–81 | year = 1988 | pmid = 3279154 | pmc = 2188834 | doi = 10.1084/jem.167.2.570 }} through binding to the receptors CCR1, CCR4 and CCR5.

Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).{{cite journal | vauthors = Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A | title = Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta | journal = The Journal of Experimental Medicine | volume = 168 | issue = 6 | pages = 2251–9 | year = 1988 | pmid = 3058856 | pmc = 2189160 | doi = 10.1084/jem.168.6.2251 }}{{cite web | title = Entrez Gene: CCL3 chemokine (C-C motif) ligand 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6348}}

CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.{{cite journal | vauthors = Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A | title = Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen | journal = Science | volume = 243 | issue = 4894 Pt 1 | pages = 1066–8 | year = 1989 | pmid = 2646711 | doi = 10.1126/science.2646711 | bibcode = 1989Sci...243.1066D }}

CCL3 has been shown to interact with CCL4.{{cite journal | vauthors = Guan E, Wang J, Norcross MA | title = Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer | journal = The Journal of Biological Chemistry | volume = 276 | issue = 15 | pages = 12404–9 | date = Apr 2001 | pmid = 11278300 | doi = 10.1074/jbc.M006327200 | doi-access = free }}

Attracts macrophages, monocytes and neutrophils.

• Macrophage inflammatory proteins

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• {{UCSC gene info|CCL3}}

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• {{cite journal | vauthors = Menten P, Wuyts A, Van Damme J | title = Macrophage inflammatory protein-1 | journal = Cytokine & Growth Factor Reviews | volume = 13 | issue = 6 | pages = 455–81 | date = Dec 2002 | pmid = 12401480 | doi = 10.1016/S1359-6101(02)00045-X }}
• {{cite journal | vauthors = Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB | title = HIV-1 Vpr and anti-inflammatory activity | journal = DNA and Cell Biology | volume = 23 | issue = 4 | pages = 239–47 | date = Apr 2004 | pmid = 15142381 | doi = 10.1089/104454904773819824 }}
• {{cite journal | vauthors = Joseph AM, Kumar M, Mitra D | title = Nef: "necessary and enforcing factor" in HIV infection | journal = Current HIV Research | volume = 3 | issue = 1 | pages = 87–94 | date = Jan 2005 | pmid = 15638726 | doi = 10.2174/1570162052773013 }}
• {{cite journal | vauthors = Zhao RY, Elder RT | title = Viral infections and cell cycle G2/M regulation | journal = Cell Research | volume = 15 | issue = 3 | pages = 143–9 | date = Mar 2005 | pmid = 15780175 | doi = 10.1038/sj.cr.7290279 | doi-access = free }}
• {{cite journal | vauthors = Zhao RY, Bukrinsky M, Elder RT | title = HIV-1 viral protein R (Vpr) & host cellular responses | journal = The Indian Journal of Medical Research | volume = 121 | issue = 4 | pages = 270–86 | date = Apr 2005 | pmid = 15817944 }}
• {{cite journal | vauthors = Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY | title = Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions | journal = Cell Research | volume = 15 | issue = 11–12 | pages = 923–34 | year = 2006 | pmid = 16354571 | doi = 10.1038/sj.cr.7290370 | doi-access = free }}

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{{PDB Gallery|geneid=6348}}

{{Chemokines}}

{{Chemokine receptor modulators}}

Category:Cytokines

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