CCNG1

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene.

CCNG1 has been shown to interact with:

• Mdm2,
• P16,{{cite journal | vauthors = Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC, Quelle DE | title = Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways | journal = Mol. Cancer Res. | volume = 1 | issue = 3 | pages = 195–206 | date = Jan 2003 | pmid = 12556559 }}
• P53, and
• PPP2R4.{{cite journal | vauthors = Okamoto K, Kamibayashi C, Serrano M, Prives C, Mumby MC, Beach D | title = p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A | journal = Mol. Cell. Biol. | volume = 16 | issue = 11 | pages = 6593–602 | date = Nov 1996 | pmid = 8887688 | pmc = 231661 | doi = 10.1128/mcb.16.11.6593}}

{{reflist}}

• {{UCSC gene info|CCNG1}}

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• {{cite journal | vauthors = Horne MC, Goolsby GL, Donaldson KL, Tran D, Neubauer M, Wahl AF | title = Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression | journal = J. Biol. Chem. | volume = 271 | issue = 11 | pages = 6050–61 | year = 1996 | pmid = 8626390 | doi = 10.1074/jbc.271.11.6050 | doi-access = free }}
• {{cite journal | vauthors = Kanaoka Y, Kimura SH, Okazaki I, Ikeda M, Nojima H | title = GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain | journal = FEBS Lett. | volume = 402 | issue = 1 | pages = 73–80 | year = 1997 | pmid = 9013862 | doi = 10.1016/S0014-5793(96)01484-6 | s2cid = 22697554 | doi-access = free }}
• {{cite journal | vauthors = Kato MV | title = The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondria | journal = Leuk. Lymphoma | volume = 33 | issue = 1–2 | pages = 181–6 | year = 1999 | pmid = 10194136 | doi = 10.3109/10428199909093740 }}
• {{cite journal | vauthors = Reimer CL, Borras AM, Kurdistani SK, Garreau JR, Chung M, Aaronson SA, Lee SW | title = Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11022–9 | year = 1999 | pmid = 10196184 | doi = 10.1074/jbc.274.16.11022 | doi-access = free }}
• {{cite journal | vauthors = Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC | title = Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest | journal = J. Biol. Chem. | volume = 277 | issue = 30 | pages = 27449–67 | year = 2002 | pmid = 11956189 | doi = 10.1074/jbc.M111693200 | doi-access = free }}
• {{cite journal | vauthors = Jordan-Sciutto KL, Morgan K, Bowser R | title = Increased Cyclin G1 Immunoreactivity During Alzheimer's Disease | journal = J. Alzheimers Dis. | volume = 1 | issue = 6 | pages = 409–417 | year = 1999 | pmid = 12214116 | doi = 10.3233/jad-1999-1605}}
• {{cite journal | vauthors = Baek WK, Kim D, Jung N, Yi YW, Kim JM, Cha SD, Bae I, Cho CH | title = Increased expression of cyclin G1 in leiomyoma compared with normal myometrium | journal = Am. J. Obstet. Gynecol. | volume = 188 | issue = 3 | pages = 634–9 | year = 2003 | pmid = 12634633 | doi = 10.1067/mob.2003.140 }}
• {{cite journal | vauthors = Li JQ, Kubo A, Wu F, Usuki H, Fujita J, Bandoh S, Masaki T, Saoo K, Takeuchi H, Kobayashi S, Imaida K, Maeta H, Ishida T, Kuriyama S | title = Cyclin B1, unlike cyclin G1, increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes | journal = Int. J. Oncol. | volume = 22 | issue = 5 | pages = 1101–10 | year = 2003 | pmid = 12684677 | doi = 10.3892/ijo.22.5.1101 }}
• {{cite journal | vauthors = Ohtsuka T, Jensen MR, Kim HG, Kim KT, Lee SW | title = The negative role of cyclin G in ATM-dependent p53 activation | journal = Oncogene | volume = 23 | issue = 31 | pages = 5405–8 | year = 2004 | pmid = 15077171 | doi = 10.1038/sj.onc.1207693 | doi-access = free }}
• {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
• {{cite journal | vauthors = Seo HR, Lee DH, Lee HJ, Baek M, Bae S, Soh JW, Lee SJ, Kim J, Lee YS | title = Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1 | journal = Cell Death Differ. | volume = 13 | issue = 9 | pages = 1475–84 | year = 2006 | pmid = 16322753 | doi = 10.1038/sj.cdd.4401822 | doi-access = free }}
• {{cite journal | vauthors = Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu CG, Calin GA, Giovannini C, Ferrazzi E, Grazi GL, Croce CM, Bolondi L, Negrini M | title = Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma | journal = Cancer Res. | volume = 67 | issue = 13 | pages = 6092–9 | year = 2007 | pmid = 17616664 | doi = 10.1158/0008-5472.CAN-06-4607 | doi-access = free }}

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