CCRL2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
C-C chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene.{{cite journal | vauthors = Fan P, Kyaw H, Su K, Zeng Z, Augustus M, Carter KC, Li Y | title = Cloning and characterization of a novel human chemokine receptor | journal = Biochem Biophys Res Commun | volume = 243 | issue = 1 | pages = 264–8 |date=Mar 1998 | pmid = 9473515 | doi = 10.1006/bbrc.1997.7981 }}{{cite web | title = Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9034}} Recently it was found that CCRL2 also acts as a receptor for the chemokine chemerin.{{cite journal | vauthors = Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC | title = Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis | journal = J. Exp. Med. | volume = 205 | issue = 10 | pages = 2207–20 |date=September 2008 | pmid = 18794339 | pmc = 2556791 | doi = 10.1084/jem.20080300 }}
Function
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.
References
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External links
- {{UCSC gene info|CCRL2}}
Further reading
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- {{cite journal | vauthors=Daugherty BL, Springer MS |title=The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. |journal=Genomics |volume=41 |issue= 2 |pages= 294–5 |year= 1997 |pmid= 9143512 |doi= 10.1006/geno.1997.4626 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Galligan CL |title=Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis |journal=Arthritis Rheum. |volume=50 |issue= 6 |pages= 1806–14 |year= 2004 |pmid= 15188357 |doi= 10.1002/art.20275 |name-list-style=vanc| author2=Matsuyama W | author3=Matsukawa A | display-authors=3 | last4=Mizuta | first4=Hiroshi | last5=Hodge | first5=David R. | last6=Howard | first6=O. M. Zack | last7=Yoshimura | first7=Teizo }}
- {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Muzny DM |title=The DNA sequence, annotation and analysis of human chromosome 3 |journal=Nature |volume=440 |issue= 7088 |pages= 1194–8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 |name-list-style=vanc| author2=Scherer SE | author3=Kaul R | display-authors=3 | last4=Wang | first4=Jing | last5=Yu | first5=Jun | last6=Sudbrak | first6=Ralf | last7=Buhay | first7=Christian J. | last8=Chen | first8=Rui | last9=Cree | first9=Andrew |bibcode=2006Natur.440.1194M | doi-access=free }}
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{{NLM content}}
{{Chemokine receptors}}
{{Cytokine receptor modulators}}
{{transmembranereceptor-stub}}