CCT3

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

CCT3 has been shown to interact with PPP4C.{{cite journal | vauthors = Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC | title = PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 | journal = The Journal of Biological Chemistry | volume = 283 | issue = 43 | pages = 29273–84 | date = Oct 2008 | pmid = 18715871 | pmc = 2662017 | doi = 10.1074/jbc.M803443200 | doi-access = free }}{{cite journal | vauthors = Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R | title = A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 11 | pages = 1725–40 | date = Nov 2005 | pmid = 16085932 | doi = 10.1074/mcp.M500231-MCP200 | doi-access = free }}

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• {{UCSC gene info|CCT3}}

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• {{cite journal | vauthors = Kubota H, Hynes G, Carne A, Ashworth A, Willison K | title = Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin | journal = Current Biology | volume = 4 | issue = 2 | pages = 89–99 | date = Feb 1994 | pmid = 7953530 | doi = 10.1016/S0960-9822(94)00024-2 | bibcode = 1994CBio....4...89K | s2cid = 31300131 }}
• {{cite journal | vauthors = Sévigny G, Joly EC, Bibor-Hardy V, Lemieux N | title = Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization | journal = Genomics | volume = 22 | issue = 3 | pages = 634–6 | date = Aug 1994 | pmid = 8001976 | doi = 10.1006/geno.1994.1438 }}
• {{cite journal | vauthors = Walkley NA, Demaine AG, Malik AN | title = Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma | journal = The Biochemical Journal | volume = 313 | issue = Pt 2 | pages = 381–9 | date = Jan 1996 | pmid = 8573069 | pmc = 1216920 | doi = 10.1042/bj3130381}}
• {{cite journal | vauthors = Feldman DE, Thulasiraman V, Ferreyra RG, Frydman J | title = Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC | journal = Molecular Cell | volume = 4 | issue = 6 | pages = 1051–61 | date = Dec 1999 | pmid = 10635329 | doi = 10.1016/S1097-2765(00)80233-6 | doi-access = free }}
• {{cite journal | vauthors = Wong N, Chan A, Lee SW, Lam E, To KF, Lai PB, Li XN, Liew CT, Johnson PJ | title = Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression | journal = Journal of Hepatology | volume = 38 | issue = 3 | pages = 298–306 | date = Mar 2003 | pmid = 12586295 | doi = 10.1016/S0168-8278(02)00412-9 }}
• {{cite journal | vauthors = Yuryev A, Wennogle LP | title = Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis | journal = Genomics | volume = 81 | issue = 2 | pages = 112–25 | date = Feb 2003 | pmid = 12620389 | doi = 10.1016/S0888-7543(02)00008-3 }}
• {{cite journal | vauthors = Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA | title = Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport | journal = Experimental Cell Research | volume = 289 | issue = 2 | pages = 211–21 | date = Oct 2003 | pmid = 14499622 | doi = 10.1016/S0014-4827(03)00261-1 }}
• {{cite journal | vauthors = Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R | title = A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death | journal = The Journal of Biological Chemistry | volume = 278 | issue = 51 | pages = 51901–10 | date = Dec 2003 | pmid = 14532270 | doi = 10.1074/jbc.M309655200 | doi-access = free }}
• {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}

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