CCT6B
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.{{cite journal | vauthors = Ozaki K, Kuroki T, Hayashi S, Nakamura Y | title = Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method | journal = Genomics | volume = 36 | issue = 2 | pages = 316–9 |date=Jan 1997 | pmid = 8812458 | doi = 10.1006/geno.1996.0467 }}{{cite journal | vauthors = Kubota H, Hynes GM, Kerr SM, Willison KR | title = Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1 | journal = FEBS Lett | volume = 402 | issue = 1 | pages = 53–6 |date=Feb 1997 | pmid = 9013858 | doi =10.1016/S0014-5793(96)01501-3 | s2cid = 1972107 | url = https://www.pure.ed.ac.uk/ws/files/12111026/Tissue_specific_subunit_of_the_mouse_cytosolic_chaperonin_containing_TCP_1.pdf | doi-access = free }}{{cite web | title = Entrez Gene: CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10693}}
This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
References
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External links
- {{UCSC gene info|CCT6B}}
Further reading
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- {{cite journal | vauthors=Stirling PC, Cuéllar J, Alfaro GA |title=PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates |journal=J. Biol. Chem. |volume=281 |issue= 11 |pages= 7012–21 |year= 2006 |pmid= 16415341 |doi= 10.1074/jbc.M513235200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
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{{gene-17-stub}}