CD120
{{Short description|Protein family}}
{{infobox protein
| Name = tumor necrosis factor receptor superfamily, member 1A
| caption =
| image =
| width =
| HGNCid = 11916
| Symbol = TNFRSF1A
| AltSymbols = CD120a, TNFR1
| EntrezGene = 7132
| OMIM = 191190
| RefSeq = NM_001065
| UniProt = P19438
| PDB =
| ECnumber =
| Chromosome = 12
| Arm = p
| Band = 13.2
| LocusSupplementaryData =
}}
{{infobox protein
| Name = tumor necrosis factor receptor superfamily, member 1B
| caption =
| image =
| width =
| HGNCid =11917
| Symbol = TNFRSF1B
| AltSymbols = CD120a, TNFR2
| EntrezGene = 7133
| OMIM = 191191
| RefSeq = NM_001066
| UniProt = P20333
| PDB =
| ECnumber =
| Chromosome = 1
| Arm = p
| Band = 36.22
| LocusSupplementaryData =
}}
CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).{{cite journal | vauthors = Locksley RM, Killeen N, Lenardo MJ | title = The TNF and TNF receptor superfamilies: integrating mammalian biology | journal = Cell | volume = 104 | issue = 4 | pages = 487–501 | year = 2001 | pmid = 11239407 | doi = 10.1016/S0092-8674(01)00237-9 | s2cid = 7657797 | doi-access = free }}{{cite journal | vauthors = Hehlgans T, Pfeffer K | title = The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games | journal = Immunology | volume = 115 | issue = 1 | pages = 1–20 | year = 2005 | pmid = 15819693 | doi = 10.1111/j.1365-2567.2005.02143.x | pmc = 1782125 }}
Receptor subtypes
There are two variants of the receptor, each encoded by a separate gene:
- CD120a - TNFR1 - TNFR superfamily member 1A
- CD120b - TNFR2 - TNFR superfamily member 1B
TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,{{cite journal | vauthors = Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW | title = The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior | journal = Psychopharmacology | volume = 201 | issue = 4 | pages = 549–56 |date=January 2009 | pmid = 18825372 | pmc = 2711641 | doi = 10.1007/s00213-008-1331-4 }} and is involved in neurotoxic processes.{{cite journal | vauthors = McCoy MK, Tansey MG | title = TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease | journal = J Neuroinflammation | volume = 5 | issue = 1| pages = 45 | year = 2008 | pmid = 18925972 | pmc = 2577641 | doi = 10.1186/1742-2094-5-45 | doi-access = free }} Elevated levels of TNFR1 has been found in severe mental disorders.{{cite journal | vauthors = Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA | title = Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor | journal = Bipolar Disord | volume = 11 | issue = 7 | pages = 726–34 |date=November 2009 | pmid = 19839997 | doi = 10.1111/j.1399-5618.2009.00757.x | hdl = 10852/34620 | hdl-access = free }}
Signaling pathway
Image:TNF signaling.jpg-R1. Dashed grey lines represent multiple steps]]
{{Clear}}
See also
References
{{reflist}}
External links
- {{MeshName|CD120a+Antigen}}
- {{MeshName|CD120b+Antigen}}
{{clusters of differentiation}}
{{Cytokine receptors}}
{{Cytokine receptor modulators}}