CD2AP

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

CD2AP has been shown to interact with:

• Cbl gene,{{cite journal | vauthors = Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I | title = Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites | journal = J. Cell Sci. | volume = 117 | issue = Pt 12 | pages = 2557–68 | date = May 2004 | pmid = 15128873 | doi = 10.1242/jcs.01148 | s2cid = 14083271 | doi-access = }}{{cite journal | vauthors = Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H | title = The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction | journal = J. Biol. Chem. | volume = 276 | issue = 7 | pages = 4957–63 | date = Feb 2001 | pmid = 11067845 | doi = 10.1074/jbc.M005784200 | doi-access = free }}{{cite journal | vauthors = Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y | title = CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl | journal = Traffic | volume = 4 | issue = 2 | pages = 97–112 | date = Feb 2003 | pmid = 12559036 | doi = 10.1034/j.1600-0854.2003.40205.x| s2cid = 38612642 | doi-access = }}
• NPHS2,{{cite journal | vauthors = Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, Holzman LB, Mundel P | title = Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin | journal = J. Clin. Invest. | volume = 108 | issue = 11 | pages = 1621–9 | date = Dec 2001 | pmid = 11733557 | pmc = 200981 | doi = 10.1172/JCI12849 }}
• Nephrin,{{cite journal | vauthors = Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG | title = Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin | journal = Am. J. Pathol. | volume = 165 | issue = 3 | pages = 923–36 | date = Sep 2004 | pmid = 15331416 | pmc = 1618613 | doi = 10.1016/S0002-9440(10)63354-8 }} and
• RAB4A.

• Focal segmental glomerulosclerosis

{{reflist}}

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• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
• {{cite journal | vauthors = Dustin ML, Olszowy MW, Holdorf AD, Li J, Bromley S, Desai N, Widder P, Rosenberger F, van der Merwe PA, Allen PM, Shaw AS | title = A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts | journal = Cell | volume = 94 | issue = 5 | pages = 667–77 | year = 1998 | pmid = 9741631 | doi = 10.1016/S0092-8674(00)81608-6| s2cid = 18042803 |url=https://zenodo.org/record/1065005 | doi-access = free }}
• {{cite journal | vauthors = Lehtonen S, Ora A, Olkkonen VM, Geng L, Zerial M, Somlo S, Lehtonen E | title = In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2 | journal = J. Biol. Chem. | volume = 275 | issue = 42 | pages = 32888–93 | year = 2000 | pmid = 10913159 | doi = 10.1074/jbc.M006624200 | doi-access = free }}
• {{cite journal | vauthors = Li C, Ruotsalainen V, Tryggvason K, Shaw AS, Miner JH | title = CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere | journal = Am. J. Physiol. Renal Physiol. | volume = 279 | issue = 4 | pages = F785–92 | year = 2000 | pmid = 10997929 | doi = 10.1152/ajprenal.2000.279.4.F785| s2cid = 37166239 | doi-access = free }}
• {{cite journal | vauthors = Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H | title = The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction | journal = J. Biol. Chem. | volume = 276 | issue = 7 | pages = 4957–63 | year = 2001 | pmid = 11067845 | doi = 10.1074/jbc.M005784200 | doi-access = free }}
• {{cite journal | vauthors = Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, Holzman LB, Mundel P | title = Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin | journal = J. Clin. Invest. | volume = 108 | issue = 11 | pages = 1621–9 | year = 2002 | pmid = 11733557 | pmc = 200981 | doi = 10.1172/JCI12849 }}
• {{cite journal | vauthors = Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT | title = Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 | journal = J. Biol. Chem. | volume = 277 | issue = 31 | pages = 28238–46 | year = 2002 | pmid = 12029088 | doi = 10.1074/jbc.M202783200 | doi-access = free }}
• {{cite journal | vauthors = Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA | title = The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse | journal = Immunity | volume = 18 | issue = 1 | pages = 141–54 | year = 2003 | pmid = 12530983 | doi = 10.1016/S1074-7613(02)00516-2 | doi-access = free }}
• {{cite journal | vauthors = Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE, Le Marchand-Brustel Y | title = CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl | journal = Traffic | volume = 4 | issue = 2 | pages = 97–112 | year = 2003 | pmid = 12559036 | doi = 10.1034/j.1600-0854.2003.40205.x | s2cid = 38612642 | doi-access = }}
• {{cite journal | vauthors = Lynch DK, Winata SC, Lyons RJ, Hughes WE, Lehrbach GM, Wasinger V, Corthals G, Cordwell S, Daly RJ | title = A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton | journal = J. Biol. Chem. | volume = 278 | issue = 24 | pages = 21805–13 | year = 2003 | pmid = 12672817 | doi = 10.1074/jbc.M211407200 | doi-access = free }}
• {{cite journal | vauthors = Hutchings NJ, Clarkson N, Chalkley R, Barclay AN, Brown MH | title = Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85 | journal = J. Biol. Chem. | volume = 278 | issue = 25 | pages = 22396–403 | year = 2003 | pmid = 12690097 | doi = 10.1074/jbc.M302540200 | doi-access = free }}
• {{cite journal | vauthors = Kim JM, Wu H, Green G, Winkler CA, Kopp JB, Miner JH, Unanue ER, Shaw AS | title = CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility | journal = Science | volume = 300 | issue = 5623 | pages = 1298–300 | year = 2003 | pmid = 12764198 | doi = 10.1126/science.1081068 | bibcode = 2003Sci...300.1298K | s2cid = 7106967 }}
• {{cite journal | vauthors = Schulze WX, Mann M | title = A novel proteomic screen for peptide-protein interactions | journal = J. Biol. Chem. | volume = 279 | issue = 11 | pages = 10756–64 | year = 2004 | pmid = 14679214 | doi = 10.1074/jbc.M309909200 | doi-access = free }}
• {{cite journal | vauthors = Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I | title = Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites | journal = J. Cell Sci. | volume = 117 | issue = Pt 12 | pages = 2557–68 | year = 2004 | pmid = 15128873 | doi = 10.1242/jcs.01148 | s2cid = 14083271 | doi-access = }}
• {{cite journal | vauthors = Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG | title = Nephrin Forms a Complex with Adherens Junction Proteins and CASK in Podocytes and in Madin-Darby Canine Kidney Cells Expressing Nephrin | journal = Am. J. Pathol. | volume = 165 | issue = 3 | pages = 923–36 | year = 2004 | pmid = 15331416 | pmc = 1618613 | doi = 10.1016/S0002-9440(10)63354-8 }}
• {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }}
• {{cite journal | vauthors = Coward RJ, Foster RR, Patton D, Ni L, Lennon R, Bates DO, Harper SJ, Mathieson PW, Saleem MA | title = Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes | journal = J. Am. Soc. Nephrol. | volume = 16 | issue = 3 | pages = 629–37 | year = 2005 | pmid = 15659563 | doi = 10.1681/ASN.2004030172 | doi-access = free }}

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• {{UCSC gene info|CD2AP}}

{{PDB Gallery|geneid=23607}}

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