CD300LF
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
CMRF35-like molecule 1, also known as CD300lf, is a protein that in humans is encoded by the CD300LF gene.{{cite journal | vauthors = Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A | display-authors = 6 | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Research | volume = 13 | issue = 10 | pages = 2265–70 | date = October 2003 | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 }}{{cite web | title = Entrez Gene: CD300LF CD300 molecule-like family member f| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=146722| access-date = }} CD300lf belongs to the protein family of CD300. CD300lf is a membrane glycoprotein that contains an immunoglobulin domain and is expressed by myeloid and mast cells{{Cite web|url=https://www.uniprot.org/uniprot/Q8TDQ1|title=CD300LF - CMRF35-like molecule 1 precursor - Homo sapiens (Human) - CD300LF gene & protein|website=www.uniprot.org|access-date=2019-03-16}} of humans and other mammals. The protein functions in immunoregulation{{cite journal | vauthors = Voss OH, Tian L, Murakami Y, Coligan JE, Krzewski K | title = Emerging role of CD300 receptors in regulating myeloid cell efferocytosis | journal = Molecular & Cellular Oncology | volume = 2 | issue = 4 | pages = e964625 | date = 2015-10-02 | pmid = 27308512 | pmc = 4905414 | doi = 10.4161/23723548.2014.964625 }} but might also have a role in norovirus infections.
CD300lf and noroviruses
CD300lf has been shown to function as the primary receptor for murine norovirus in mice,{{cite journal | vauthors = Nelson CA, Wilen CB, Dai YN, Orchard RC, Kim AS, Stegeman RA, Hsieh LL, Smith TJ, Virgin HW, Fremont DH | title = Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 115 | issue = 39 | pages = E9201–E9210 | date = September 2018 | pmid = 30194229 | pmc = 6166816 | doi = 10.1073/pnas.1805797115 | bibcode = 2018PNAS..115E9201N | doi-access = free }}{{cite journal | vauthors = Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW | title = Discovery of a proteinaceous cellular receptor for a norovirus | journal = Science | volume = 353 | issue = 6302 | pages = 933–6 | date = August 2016 | pmid = 27540007 | pmc = 5484048 | doi = 10.1126/science.aaf1220 | bibcode = 2016Sci...353..933O }} Human norovirus does not use the same receptor in viral entry.{{cite journal | vauthors = Graziano VR, Walker FC, Kennedy EA, Wei J, Ettayebi K, Strine MS, Filler RB, Hassan E, Hsieh LL, Kim AS, Kolawole AO, Wobus CE, Lindesmith LC, Baric RS, Estes MK, Orchard RC, Baldridge MT, Wilen CB | display-authors = 6 | title = CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus | journal = PLOS Pathogens | volume = 16 | issue = 4 | pages = e1008242 | date = April 2020 | pmid = 32251490 | pmc = 7162533 | doi = 10.1371/journal.ppat.1008242 | doi-access = free }} Human and murine CD300lf proteins have about 59% identity in their immunoglobulin domains, with most of that variation occurring in parts of the protein called CDR3 and the CC’loop.{{cite journal | vauthors = Márquez JA, Galfré E, Dupeux F, Flot D, Moran O, Dimasi N | title = The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1 | journal = Journal of Molecular Biology | volume = 367 | issue = 2 | pages = 310–8 | date = March 2007 | pmid = 17275839 | doi = 10.1016/j.jmb.2007.01.011 }} Murine norovirus binds to a cleft between these domains. The differences between murine and human CD300lf contribute to murine norovirus host species restriction, as incorporating murine CD300lf into human cells makes them susceptible to infection by the murine virus.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR | title = CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation | journal = Journal of Immunology | volume = 171 | issue = 12 | pages = 6541–8 | date = December 2003 | pmid = 14662855 | doi = 10.4049/jimmunol.171.12.6541 | doi-access = free }}
- {{cite journal | vauthors = Sui L, Li N, Liu Q, Zhang W, Wan T, Wang B, Luo K, Sun H, Cao X | title = IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes | journal = Biochemical and Biophysical Research Communications | volume = 319 | issue = 3 | pages = 920–8 | date = July 2004 | pmid = 15184070 | doi = 10.1016/j.bbrc.2004.05.065 }}
- {{cite journal | vauthors = Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites | journal = Protein Science | volume = 13 | issue = 10 | pages = 2819–24 | date = October 2004 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }}
- {{cite journal | vauthors = Alvarez-Errico D, Aguilar H, Kitzig F, Brckalo T, Sayós J, López-Botet M | title = IREM-1 is a novel inhibitory receptor expressed by myeloid cells | journal = European Journal of Immunology | volume = 34 | issue = 12 | pages = 3690–701 | date = December 2004 | pmid = 15549731 | doi = 10.1002/eji.200425433 | doi-access = free }}
- {{cite journal | vauthors = Alvarez-Errico D, Sayós J, López-Botet M | title = The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase | journal = Journal of Immunology | volume = 178 | issue = 2 | pages = 808–16 | date = January 2007 | pmid = 17202342 | doi = 10.4049/jimmunol.178.2.808 | doi-access = free }}
{{refend}}
{{PDB Gallery|geneid=146722}}
External links
- {{UCSC gene info|CD300LF}}
{{gene-17-stub}}