CD43

Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.

Defects in the CD43 molecule are associated with the development of Wiskott–Aldrich syndrome.{{cite journal | vauthors = Remold-O'Donnell E, Rosen FS | title = Sialophorin (CD43) and the Wiskott–Aldrich syndrome | journal = Immunodefic Rev | volume = 2 | issue = 2 | pages = 151–74 | year = 1990 | pmid = 2223062 }} It also appears in about 25% of intestinal MALTomas.{{citation needed|date=June 2011}} Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours. Although it is present in over 90% of T-cell lymphomas, it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a panel to demonstrate B-cell lymphoblastic lymphoma, since the malignant cells in this condition are often CD43 positive, and may be difficult to stain with other antibodies. Because it stains granulocytes and their precursors, it is also an effective marker for myeloid tumours.{{cite book|author=Leong, Anthony S-Y|author2=Cooper, Kumarason|author3=Leong, F Joel W-M|year=2003|title=Manual of Diagnostic Cytology|edition=2nd|publisher=Greenwich Medical Media, Ltd.|page=113|isbn=978-1-84110-100-2}}

CD43 has been shown to interact with EZR{{cite journal | vauthors = Serrador JM, Nieto M, Alonso-Lebrero JL, del Pozo MA, Calvo J, Furthmayr H, Schwartz-Albiez R, Lozano F, González-Amaro R, Sánchez-Mateos P, Sánchez-Madrid F | title = CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts | journal = Blood | volume = 91 | issue = 12 | pages = 4632–44 |date=June 1998 | pmid = 9616160 | doi = 10.1182/blood.V91.12.4632}} and Moesin.{{cite journal | vauthors = Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S | title = Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2 | journal = J. Cell Biol. | volume = 140 | issue = 4 | pages = 885–95 |date=February 1998 | pmid = 9472040 | pmc = 2141743 | doi = 10.1083/jcb.140.4.885}}

{{reflist}}

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• {{cite journal | vauthors=Fukuda M, Carlsson SR |title=Leukosialin, a major sialoglycoprotein on human leukocytes as differentiation antigens. |journal=Med. Biol. |volume=64 |issue= 6 |pages= 335–43 |year= 1987 |pmid= 2950285 }}
• {{cite journal | vauthors=Rogaev EI, Keryanov SA |title=Unusual variability of the complex dinucleotide repeat block at the SPN locus. |journal=Hum. Mol. Genet. |volume=1 |issue= 8 |page= 657 |year= 1993 |pmid= 1301183 |doi=10.1093/hmg/1.8.657 }}
• {{cite journal | vauthors=Rosenstein Y, Park JK, Hahn WC |title=CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. |journal=Nature |volume=354 |issue= 6350 |pages= 233–5 |year= 1992 |pmid= 1683685 |doi= 10.1038/354233a0 |bibcode=1991Natur.354..233R|s2cid=4256329 |display-authors=etal}}
• {{cite journal | vauthors=Schmid K, Hediger MA, Brossmer R |title=Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 2 |pages= 663–7 |year= 1992 |pmid= 1731338 |doi=10.1073/pnas.89.2.663 | pmc=48299 |bibcode = 1992PNAS...89..663S |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Kudo S, Fukuda M |title=A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes. |journal=J. Biol. Chem. |volume=266 |issue= 13 |pages= 8483–9 |year= 1991 |doi=10.1016/S0021-9258(18)93000-0 |pmid= 1827122 |doi-access=free }}
• {{cite journal | vauthors=Park JK, Rosenstein YJ, Remold-O'Donnell E |title=Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. |journal=Nature |volume=350 |issue= 6320 |pages= 706–9 |year= 1991 |pmid= 2023632 |doi= 10.1038/350706a0 |bibcode = 1991Natur.350..706P |s2cid=4335838 |display-authors=etal}}
• {{cite journal | vauthors=Shelley CS, Remold-O'Donnell E, Rosen FS, Whitehead AS |title=Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins. |journal=Biochem. J. |volume=270 |issue= 3 |pages= 569–76 |year= 1990 |pmid= 2241892 |doi= 10.1042/bj2700569| pmc=1131770 }}
• {{cite journal | vauthors=Srinivas RV, Su T, Trimble LA |title=Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43. |journal=AIDS Res. Hum. Retroviruses |volume=11 |issue= 9 |pages= 1015–21 |year= 1996 |pmid= 8554898 |doi=10.1089/aid.1995.11.1015 |display-authors=etal}}
• {{cite journal | vauthors=Hirao M, Sato N, Kondo T |title=Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. |journal=J. Cell Biol. |volume=135 |issue= 1 |pages= 37–51 |year= 1996 |pmid= 8858161 |doi=10.1083/jcb.135.1.37 | pmc=2121020 |display-authors=etal}}
• {{cite journal | vauthors=Yonemura S, Hirao M, Doi Y |title=Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. |journal=J. Cell Biol. |volume=140 |issue= 4 |pages= 885–95 |year= 1998 |pmid= 9472040 |doi=10.1083/jcb.140.4.885 | pmc=2141743 |display-authors=etal}}
• {{cite journal | vauthors=Pedraza-Alva G, Mérida LB, Burakoff SJ, Rosenstein Y |title=T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation. |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14218–24 |year= 1998 |pmid= 9603925 |doi=10.1074/jbc.273.23.14218 |doi-access=free }}
• {{cite journal | vauthors=Serrador JM, Nieto M, Alonso-Lebrero JL |title=CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. |journal=Blood |volume=91 |issue= 12 |pages= 4632–44 |year= 1998 |pmid= 9616160 |doi= 10.1182/blood.V91.12.4632|display-authors=etal}}
• {{cite journal | vauthors=Pace KE, Lee C, Stewart PL, Baum LG |title=Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. |journal=J. Immunol. |volume=163 |issue= 7 |pages= 3801–11 |year= 1999 |doi=10.4049/jimmunol.163.7.3801 |pmid= 10490978 |doi-access=free }}
• {{cite journal | vauthors=Seveau S, Keller H, Maxfield FR |title=Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule. |journal=Blood |volume=95 |issue= 8 |pages= 2462–70 |year= 2000 |pmid= 10753822 |doi= 10.1182/blood.V95.8.2462|display-authors=etal}}
• {{cite journal | vauthors=Fratazzi C, Manjunath N, Arbeit RD |title=A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. |journal=J. Exp. Med. |volume=192 |issue= 2 |pages= 183–92 |year= 2000 |pmid= 10899905 |doi=10.1084/jem.192.2.183 | pmc=2193255 |display-authors=etal}}
• {{cite journal | vauthors=Santana MA, Pedraza-Alva G, Olivares-Zavaleta N |title=CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31460–8 |year= 2000 |pmid= 10908570 |doi= 10.1074/jbc.M005231200 |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=van den Berg TK, Nath D, Ziltener HJ |title=Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). |journal=J. Immunol. |volume=166 |issue= 6 |pages= 3637–40 |year= 2001 |pmid= 11238599 |doi= 10.4049/jimmunol.166.6.3637|display-authors=etal|doi-access=free }}

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• {{MeshName|CD43+antigen}}
• {{UCSC gene info|SPN}}

{{Clusters of differentiation}}

{{Glycoproteins}}

Category:Clusters of differentiation

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