CDC14A
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.{{cite journal | vauthors = Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE | title = A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast | journal = J Biol Chem | volume = 272 | issue = 47 | pages = 29403–6 |date=December 1997 | pmid = 9367992 | doi =10.1074/jbc.272.47.29403 | doi-access = free }}{{cite journal | vauthors = Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH | title = Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene | journal = Genomics | volume = 59 | issue = 2 | pages = 248–51 |date=September 1999 | pmid = 10409437 | doi = 10.1006/geno.1999.5863 }}{{cite web | title = Entrez Gene: CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8556}}
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.
Interactions
CDC14A has been shown to interact with P53, de-phosphorylate p53 at Serine 315 and thereby stabilize p53.{{cite journal |last=Li |first=L |author2=Ljungman M|author3=Dixon J E |date=January 2000 |title=The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 at Serine 315 |journal=J. Biol. Chem. |volume=275 |issue=4 |pages=2410–4 | issn = 0021-9258| pmid = 10644693 |doi=10.1074/jbc.275.4.2410 |doi-access=free }} S315-phosphorylated p53, in contrast to other p53 phosphorylation, was shown to facilitate p53 degradation.{{cite journal |last=Li |first=Y |author2=Cui K|author3=Zhang Q |author4=Li X |author5=Lin X |author6=Tang Y |author7=Prochownik E |author8=Li Y |date=July 2021 |title=FBXL6 degrades phosphorylated p53 to promote tumor growth |journal=Cell Death Differ. |volume=28 |issue=7 |pages=2112–2125 | issn = 1350-9047| pmid = 33568778 |doi=10.1038/s41418-021-00739-6 |pmc=8257708 |doi-access=free }}
References
{{reflist}}
External links
- {{UCSC gene info|CDC14A}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Li L, Ljungman M, Dixon JE |title=The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2410–4 |year= 2000 |pmid= 10644693 |doi=10.1074/jbc.275.4.2410 |doi-access=free }}
- {{cite journal | vauthors=Bembenek J, Yu H |title=Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48237–42 |year= 2002 |pmid= 11598127 |doi= 10.1074/jbc.M108126200 |doi-access= free}}
- {{cite journal | vauthors=Mailand N, Lukas C, Kaiser BK |title=Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation |journal=Nat. Cell Biol. |volume=4 |issue= 4 |pages= 317–22 |year= 2002 |pmid= 11901424 |doi= 10.1038/ncb777 |s2cid=28955777 |display-authors=etal}}
- {{cite journal | vauthors=Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK |title=Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2289–300 |year= 2003 |pmid= 12134069 |doi= 10.1091/mbc.01-11-0535 | pmc=117313 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Gruneberg U, Neef R, Honda R |title=Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 |journal=J. Cell Biol. |volume=166 |issue= 2 |pages= 167–72 |year= 2004 |pmid= 15263015 |doi= 10.1083/jcb.200403084 | pmc=2172317 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP |title=Functional homology among human and fission yeast Cdc14 phosphatases |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 29144–50 |year= 2005 |pmid= 15911625 |doi= 10.1074/jbc.M413328200 |doi-access= free |hdl= 10366/157107 |hdl-access= free }}
- {{cite journal | vauthors=Zhao H, Wang Q, Zhang H |title=UXT is a novel centrosomal protein essential for cell viability |journal=Mol. Biol. Cell |volume=16 |issue= 12 |pages= 5857–65 |year= 2006 |pmid= 16221885 |doi= 10.1091/mbc.E05-08-0705 | pmc=1289427 |display-authors=etal}}
- {{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
- {{cite journal | vauthors=Sanchez M, Galy B, Dandekar T |title=Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy |journal=J. Biol. Chem. |volume=281 |issue= 32 |pages= 22865–74 |year= 2006 |pmid= 16760464 |doi= 10.1074/jbc.M603876200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Paulsen MT, Starks AM, Derheimer FA |title=The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers |journal=Mol. Cancer |volume=5 |pages= 25 |year= 2006 |pmid= 16784539 |doi= 10.1186/1476-4598-5-25 | pmc=1524803 |display-authors=etal |doi-access=free }}
- {{cite journal | vauthors=Esteban V, Vázquez-Novelle MD, Calvo E |title=Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320 |journal=Cell Cycle |volume=5 |issue= 24 |pages= 2894–8 |year= 2007 |pmid= 17172867 |doi= 10.4161/cc.5.24.3566|display-authors=etal|doi-access=free |hdl=10261/60508 |hdl-access=free }}
- {{cite journal | vauthors=Lanzetti L, Margaria V, Melander F |title=Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells |journal=J. Biol. Chem. |volume=282 |issue= 20 |pages= 15258–70 |year= 2007 |pmid= 17371873 |doi= 10.1074/jbc.M700914200 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Yuan K, Hu H, Guo Z |title=Phospho-regulation of HsCdc14A By Polo-like kinase 1 is essential for mitotic progression |journal=J. Biol. Chem. |volume=282 |issue= 37 |pages= 27414–23 |year= 2007 |pmid= 17623655 |doi= 10.1074/jbc.M703555200 |display-authors=etal|doi-access=free }}
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{{Protein tyrosine phosphatases}}
{{gene-1-stub}}