CDC14B

CDC14B has been shown to interact with p53, potentially de-phosphorylate p53 at Serine 315 and thereby stabilize p53.{{cite journal | vauthors = Li L, Ljungman M, Dixon JE | title = The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 4 | pages = 2410–2414 | date = January 2000 | pmid = 10644693 | doi = 10.1074/jbc.275.4.2410 | doi-access = free }} S315-phosphorylated p53, in contrast to other p53 phosphorylation, was shown to facilitate p53 degradation.{{cite journal |last=Li |first=Y |author2=Cui K|author3=Zhang Q |author4=Li X |author5=Lin X |author6=Tang Y |author7=Prochownik E |author8=Li Y |date=July 2021 |title=FBXL6 degrades phosphorylated p53 to promote tumor growth |journal=Cell Death Differ. |volume=28 |issue=7 |pages=2112–2125 | issn = 1350-9047| pmid = 33568778 |doi=10.1038/s41418-021-00739-6 |pmc=8257708 |doi-access=free }} At the patho-physiological level, mice with CDC14B deletion were shown to exhibit early-onset ageing phenotypes. {{cite journal | vauthors = Wei Z, Peddibhotla S, Lin H, Fang X, Li M, Rosen M, Zhang P | title = Early-onset aging and defective DNA damage response in Cdc14b-deficient mice | journal = Mol. Cell. Biol. | volume = 31 | issue = 7 | pages = 1470–1477 | date = April 2011 | pmid = 21262768 | doi = 10.1128/MCB.01330-10 | pmc = 3135283 | doi-access = free }}

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• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 | name-list-style = vanc }}
• {{cite journal | vauthors = Li L, Ljungman M, Dixon JE | title = The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 4 | pages = 2410–2414 | date = January 2000 | pmid = 10644693 | doi = 10.1074/jbc.275.4.2410 | doi-access = free }}
• {{cite journal | vauthors = Mailand N, Lukas C, Kaiser BK, Jackson PK, Bartek J, Lukas J | title = Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation | journal = Nature Cell Biology | volume = 4 | issue = 4 | pages = 317–322 | date = April 2002 | pmid = 11901424 | doi = 10.1038/ncb777 | name-list-style = vanc | s2cid = 28955777 }}
• {{cite journal | vauthors = Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK | title = Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase | journal = Molecular Biology of the Cell | volume = 13 | issue = 7 | pages = 2289–2300 | date = July 2002 | pmid = 12134069 | pmc = 117313 | doi = 10.1091/mbc.01-11-0535 }}
• {{cite journal | vauthors = Dryden SC, Nahhas FA, Nowak JE, Goustin AS, Tainsky MA | title = Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle | journal = Molecular and Cellular Biology | volume = 23 | issue = 9 | pages = 3173–3185 | date = May 2003 | pmid = 12697818 | pmc = 153197 | doi = 10.1128/MCB.23.9.3173-3185.2003 | name-list-style = vanc }}
• {{cite journal | vauthors = Gray CH, Good VM, Tonks NK, Barford D | title = The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase | journal = The EMBO Journal | volume = 22 | issue = 14 | pages = 3524–3535 | date = July 2003 | pmid = 12853468 | pmc = 165618 | doi = 10.1093/emboj/cdg348 }}
• {{cite journal | vauthors = Nalepa G, Harper JW | title = Visualization of a highly organized intranuclear network of filaments in living mammalian cells | journal = Cell Motility and the Cytoskeleton | volume = 59 | issue = 2 | pages = 94–108 | date = October 2004 | pmid = 15362113 | doi = 10.1002/cm.20023 }}
• {{cite journal | vauthors = Cho HP, Liu Y, Gomez M, Dunlap J, Tyers M, Wang Y | title = The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules | journal = Molecular and Cellular Biology | volume = 25 | issue = 11 | pages = 4541–4551 | date = June 2005 | pmid = 15899858 | pmc = 1140622 | doi = 10.1128/MCB.25.11.4541-4551.2005 | name-list-style = vanc }}
• {{cite journal | vauthors = Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP | title = Functional homology among human and fission yeast Cdc14 phosphatases | journal = The Journal of Biological Chemistry | volume = 280 | issue = 32 | pages = 29144–29150 | date = August 2005 | pmid = 15911625 | doi = 10.1074/jbc.M413328200 | doi-access = free | hdl = 10366/157107 | hdl-access = free }}

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• {{UCSC gene info|CDC14B}}

{{PDB Gallery|geneid=8555}}

{{Protein tyrosine phosphatases}}

{{protein-stub}}