CDC16

This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.

CDC16 has been shown to interact with CDC27{{cite journal | vauthors = Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM | title = TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 | journal = Current Biology | volume = 13 | issue = 17 | pages = 1459–68 | date = Sep 2003 | pmid = 12956947 | doi = 10.1016/S0960-9822(03)00581-5 | s2cid = 5942532 | doi-access = free | bibcode = 2003CBio...13.1459V }}{{cite journal | vauthors = Ollendorff V, Donoghue DJ | title = The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex | journal = The Journal of Biological Chemistry | volume = 272 | issue = 51 | pages = 32011–8 | date = Dec 1997 | pmid = 9405394 | doi = 10.1074/jbc.272.51.32011 | doi-access = free }}{{cite journal | vauthors = Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ | title = Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events | journal = The Journal of Cell Biology | volume = 141 | issue = 6 | pages = 1393–406 | date = Jun 1998 | pmid = 9628895 | pmc = 2132789 | doi = 10.1083/jcb.141.6.1393 }}{{cite journal | vauthors = Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM | title = The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 16 | pages = 8973–8 | date = Aug 2000 | pmid = 10922056 | pmc = 16806 | doi = 10.1073/pnas.97.16.8973 | bibcode = 2000PNAS...97.8973G | doi-access = free }} and CDC20.{{cite journal | vauthors = Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ | title = Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells | journal = The Journal of Cell Biology | volume = 158 | issue = 5 | pages = 841–7 | date = Sep 2002 | pmid = 12196507 | pmc = 2173153 | doi = 10.1083/jcb.200201135 }}{{cite journal | vauthors = Nilsson J, Yekezare M, Minshull J, Pines J | title = The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction | journal = Nature Cell Biology | volume = 10 | issue = 12 | pages = 1411–20 | date = Dec 2008 | pmid = 18997788 | pmc = 2635557 | doi = 10.1038/ncb1799 }}

{{reflist}}

• {{UCSC gene info|CDC16}}

{{refbegin | 2}}

• {{cite journal | vauthors = Ollendorff V, Donoghue DJ | title = The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex | journal = The Journal of Biological Chemistry | volume = 272 | issue = 51 | pages = 32011–8 | date = Dec 1997 | pmid = 9405394 | doi = 10.1074/jbc.272.51.32011 | doi-access = free }}
• {{cite journal | vauthors = Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW | title = Identification of a cullin homology region in a subunit of the anaphase-promoting complex | journal = Science | volume = 279 | issue = 5354 | pages = 1219–22 | date = Feb 1998 | pmid = 9469815 | doi = 10.1126/science.279.5354.1219 | bibcode = 1998Sci...279.1219Y }}
• {{cite journal | vauthors = Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ | title = Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events | journal = The Journal of Cell Biology | volume = 141 | issue = 6 | pages = 1393–406 | date = Jun 1998 | pmid = 9628895 | pmc = 2132789 | doi = 10.1083/jcb.141.6.1393 }}
• {{cite journal | vauthors = Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM | title = Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex | journal = The Journal of Biological Chemistry | volume = 274 | issue = 20 | pages = 14500–7 | date = May 1999 | pmid = 10318877 | doi = 10.1074/jbc.274.20.14500 | doi-access = free }}
• {{cite journal | vauthors = Chan GK, Jablonski SA, Sudakin V, Hittle JC, Yen TJ | title = Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC | journal = The Journal of Cell Biology | volume = 146 | issue = 5 | pages = 941–54 | date = Sep 1999 | pmid = 10477750 | pmc = 2169490 | doi = 10.1083/jcb.146.5.941 }}
• {{cite journal | vauthors = Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM | title = Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 20 | pages = 11317–22 | date = Sep 1999 | pmid = 10500174 | pmc = 18031 | doi = 10.1073/pnas.96.20.11317 | bibcode = 1999PNAS...9611317G | doi-access = free }}
• {{cite journal | vauthors = Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM | title = The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 16 | pages = 8973–8 | date = Aug 2000 | pmid = 10922056 | pmc = 16806 | doi = 10.1073/pnas.97.16.8973 | bibcode = 2000PNAS...97.8973G | doi-access = free }}
• {{cite journal | vauthors = Jörgensen PM, Gräslund S, Betz R, Ståhl S, Larsson C, Höög C | title = Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex | journal = Gene | volume = 262 | issue = 1–2 | pages = 51–9 | date = Jan 2001 | pmid = 11179667 | doi = 10.1016/S0378-1119(00)00511-4 }}
• {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
• {{cite journal | vauthors = Stroschein SL, Bonni S, Wrana JL, Luo K | title = Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN | journal = Genes & Development | volume = 15 | issue = 21 | pages = 2822–36 | date = Nov 2001 | pmid = 11691834 | pmc = 312804 | doi = 10.1101/gad.912901 }}
• {{cite journal | vauthors = Yasui K, Arii S, Zhao C, Imoto I, Ueda M, Nagai H, Emi M, Inazawa J | title = TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas | journal = Hepatology | volume = 35 | issue = 6 | pages = 1476–84 | date = Jun 2002 | pmid = 12029633 | doi = 10.1053/jhep.2002.33683 | doi-access = free }}
• {{cite journal | vauthors = Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ | title = Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells | journal = The Journal of Cell Biology | volume = 158 | issue = 5 | pages = 841–7 | date = Sep 2002 | pmid = 12196507 | pmc = 2173153 | doi = 10.1083/jcb.200201135 }}
• {{cite journal | vauthors = Wang Q, Moyret-Lalle C, Couzon F, Surbiguet-Clippe C, Saurin JC, Lorca T, Navarro C, Puisieux A | title = Alterations of anaphase-promoting complex genes in human colon cancer cells | journal = Oncogene | volume = 22 | issue = 10 | pages = 1486–90 | date = Mar 2003 | pmid = 12629511 | doi = 10.1038/sj.onc.1206224 | doi-access = free }}
• {{cite journal | vauthors = Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM | title = TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 | journal = Current Biology | volume = 13 | issue = 17 | pages = 1459–68 | date = Sep 2003 | pmid = 12956947 | doi = 10.1016/S0960-9822(03)00581-5 | s2cid = 5942532 | doi-access = free | bibcode = 2003CBio...13.1459V }}
• {{cite journal | vauthors = Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM | title = Mitotic regulation of the human anaphase-promoting complex by phosphorylation | journal = The EMBO Journal | volume = 22 | issue = 24 | pages = 6598–609 | date = Dec 2003 | pmid = 14657031 | pmc = 291822 | doi = 10.1093/emboj/cdg627 }}
• {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}

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