CDC23

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.

CDC23 has been shown to interact with CDC27.{{cite journal | vauthors = Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM | title = TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 | journal = Current Biology | volume = 13 | issue = 17 | pages = 1459–68 | date = Sep 2003 | pmid = 12956947 | doi = 10.1016/S0960-9822(03)00581-5 | doi-access = free | bibcode = 2003CBio...13.1459V }}{{cite journal | vauthors = Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM | title = The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 16 | pages = 8973–8 | date = Aug 2000 | pmid = 10922056 | pmc = 16806 | doi = 10.1073/pnas.97.16.8973 | bibcode = 2000PNAS...97.8973G | doi-access = free }}

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• {{UCSC gene info|CDC23}}

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