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CDC42EP2

{{Short description|Protein-coding gene in humans}}

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Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.{{cite journal | vauthors = Joberty G, Perlungher RR, Macara IG | title = The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 10 | pages = 6585–97 | date = Oct 1999 | pmid = 10490598 | pmc = 84628 | doi = 10.1128/MCB.19.10.6585}}{{cite journal | vauthors = Hirsch DS, Pirone DM, Burbelo PD | title = A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes | journal = The Journal of Biological Chemistry | volume = 276 | issue = 2 | pages = 875–83 | date = Jan 2001 | pmid = 11035016 | doi = 10.1074/jbc.M007039200 | doi-access = free }}{{cite web | title = Entrez Gene: CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10435}}

Function

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.

Interactions

CDC42EP2 has been shown to interact with CDC42 and RHOQ.

References

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External links

  • {{UCSC gene info|CDC42EP2}}

Further reading

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  • {{cite journal | vauthors = Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC | title = A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus | journal = Genome Research | volume = 7 | issue = 7 | pages = 725–35 | date = Jul 1997 | pmid = 9253601 | pmc = 310681 | doi = 10.1101/gr.7.7.725 }}
  • {{cite journal | vauthors = Burbelo PD, Snow DM, Bahou W, Spiegel S | title = MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 16 | pages = 9083–8 | date = Aug 1999 | pmid = 10430899 | pmc = 17736 | doi = 10.1073/pnas.96.16.9083 | doi-access = free | bibcode = 1999PNAS...96.9083B }}
  • {{cite journal | vauthors = Joberty G, Perlungher RR, Sheffield PJ, Kinoshita M, Noda M, Haystead T, Macara IG | title = Borg proteins control septin organization and are negatively regulated by Cdc42 | journal = Nature Cell Biology | volume = 3 | issue = 10 | pages = 861–6 | date = Oct 2001 | pmid = 11584266 | doi = 10.1038/ncb1001-861 | s2cid = 58805 }}
  • {{cite journal | vauthors = Xue Y, Bi F, Zhang X, Zhang S, Pan Y, Liu N, Shi Y, Yao X, Zheng Y, Fan D | title = Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation | journal = International Journal of Cancer | volume = 118 | issue = 12 | pages = 2965–72 | date = Jun 2006 | pmid = 16395716 | doi = 10.1002/ijc.21763 | s2cid = 39137777 | doi-access = free }}

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