CDCA5
{{Short description|Protein-coding gene in the species Homo sapiens}}
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WP:SE{{Infobox_gene}}
Sororin is a protein that in humans is encoded by the CDCA5 gene.{{cite journal | author = Walker MG | title = Drug target discovery by gene expression analysis: cell cycle genes | journal = Curr Cancer Drug Targets | volume = 1 | issue = 1 | pages = 73–83 |date=Aug 2002 | pmid = 12188893 | doi =10.2174/1568009013334241 }}{{cite journal | vauthors = Rankin S, Ayad NG, Kirschner MW | title = Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates | journal = Mol Cell | volume = 18 | issue = 2 | pages = 185–200 |date=Apr 2005 | pmid = 15837422 | doi = 10.1016/j.molcel.2005.03.017 | doi-access = free }}{{cite web | title = Entrez Gene: CDCA5 cell division cycle associated 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113130}}
Function
Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.{{Cite journal | last1 = Schmitz | first1 = J. | last2 = Watrin | first2 = E. | last3 = Lénárt | first3 = P. | last4 = Mechtler | first4 = K. | last5 = Peters | first5 = JM. | title = Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. | journal = Curr Biol | volume = 17 | issue = 7 | pages = 630–6 |date=Apr 2007 | doi = 10.1016/j.cub.2007.02.029 | pmid = 17349791 | bibcode = 2007CBio...17..630S | hdl = 21.11116/0000-0002-101C-D | s2cid = 11988060 | hdl-access = free }}
Clinical significance
Transactivation of Sororin and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation.{{Cite journal | last1 = Nguyen | first1 = MH. | last2 = Koinuma | first2 = J. | last3 = Ueda | first3 = K. | last4 = Ito | first4 = T. | last5 = Tsuchiya | first5 = E. | last6 = Nakamura | first6 = Y. | last7 = Daigo | first7 = Y. | title = Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. | journal = Cancer Res | volume = 70 | issue = 13 | pages = 5337–47 |date=Jul 2010 | doi = 10.1158/0008-5472.CAN-09-4372 | pmid = 20551060 | doi-access = free }}
References
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Further reading
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- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 |display-authors=etal}}
- {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Schmitz J, Watrin E, Lénárt P |title=Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. |journal=Curr. Biol. |volume=17 |issue= 7 |pages= 630–6 |year= 2007 |pmid= 17349791 |doi= 10.1016/j.cub.2007.02.029 |bibcode=2007CBio...17..630S |display-authors=etal|hdl=21.11116/0000-0002-101C-D |s2cid=11988060 |hdl-access=free }}
- {{cite journal | vauthors=Díaz-Martínez LA, Giménez-Abián JF, Clarke DJ |title=Regulation of centromeric cohesion by sororin independently of the APC/C. |journal=Cell Cycle |volume=6 |issue= 6 |pages= 714–24 |year= 2007 |pmid= 17361102 |doi=10.4161/cc.6.6.3935 |doi-access=free }}
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External links
- {{UCSC gene info|CDCA5}}
{{gene-11-stub}}