CDCA8
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Borealin is a protein that in humans is encoded by the CDCA8 gene.{{cite journal | vauthors = Walker MG | title = Drug target discovery by gene expression analysis: cell cycle genes | journal = Current Cancer Drug Targets | volume = 1 | issue = 1 | pages = 73–83 | date = May 2001 | pmid = 12188893 | doi = 10.2174/1568009013334241 }}{{cite journal | vauthors = Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H | title = The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly | journal = Cell | volume = 118 | issue = 2 | pages = 187–202 | date = Jul 2004 | pmid = 15260989 | doi = 10.1016/j.cell.2004.06.026 | doi-access = free }}{{cite web | title = Entrez Gene: CDCA8 cell division cycle associated 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55143}}
Function
CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.{{cite journal | vauthors = Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC | title = Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle | journal = The Journal of Cell Biology | volume = 166 | issue = 2 | pages = 179–91 | date = Jul 2004 | pmid = 15249581 | doi = 10.1083/jcb.200404001 | pmc=2172304}}
Interactions
CDCA8 has been shown to interact with INCENP, Survivin and Aurora B kinase.
References
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Further reading
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- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors = Sauer G, Körner R, Hanisch A, Ries A, Nigg EA, Silljé HH | title = Proteome analysis of the human mitotic spindle | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 1 | pages = 35–43 | date = Jan 2005 | pmid = 15561729 | doi = 10.1074/mcp.M400158-MCP200 | doi-access = free }}
- {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = Jan 2005 | pmid = 15635413 | doi = 10.1038/nature03207 | bibcode = 2005Natur.433...77A | s2cid = 4344740 }}
- {{cite journal | vauthors = Vader G, Kauw JJ, Medema RH, Lens SM | title = Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody | journal = EMBO Reports | volume = 7 | issue = 1 | pages = 85–92 | date = Jan 2006 | pmid = 16239925 | pmc = 1369225 | doi = 10.1038/sj.embor.7400562 }}
- {{cite journal | vauthors = Noton EA, Colnaghi R, Tate S, Starck C, Carvalho A, Ko Ferrigno P, Wheatley SP | title = Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis | journal = The Journal of Biological Chemistry | volume = 281 | issue = 2 | pages = 1286–95 | date = Jan 2006 | pmid = 16291752 | doi = 10.1074/jbc.M508773200 | doi-access = free }}
- {{cite journal | vauthors = Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM | title = Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer | journal = Experimental Cell Research | volume = 312 | issue = 7 | pages = 962–73 | date = Apr 2006 | pmid = 16427043 | doi = 10.1016/j.yexcr.2005.12.015 }}
- {{cite journal | vauthors = Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH | title = Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres | journal = Molecular Biology of the Cell | volume = 17 | issue = 4 | pages = 1897–909 | date = Apr 2006 | pmid = 16436504 | pmc = 1415303 | doi = 10.1091/mbc.E05-08-0727 }}
- {{cite journal | vauthors = Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G | title = Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown | journal = Oncogene | volume = 25 | issue = 35 | pages = 4867–79 | date = Aug 2006 | pmid = 16547492 | doi = 10.1038/sj.onc.1209499 | s2cid = 27074707 | doi-access = }}
- {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}
- {{cite journal | vauthors = Klein UR, Nigg EA, Gruneberg U | title = Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP | journal = Molecular Biology of the Cell | volume = 17 | issue = 6 | pages = 2547–58 | date = Jun 2006 | pmid = 16571674 | pmc = 1474794 | doi = 10.1091/mbc.E05-12-1133 }}
- {{cite journal | vauthors = Kaur H, Stiff AC, Date DA, Taylor WR | title = Analysis of mitotic phosphorylation of borealin | journal = BMC Cell Biology | volume = 8 | pages = 5 | year = 2007 | pmid = 17241471 | pmc = 1794407 | doi = 10.1186/1471-2121-8-5 | doi-access = free }}
- {{cite journal | vauthors = Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y | title = Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis | journal = Cancer Research | volume = 67 | issue = 9 | pages = 4113–22 | date = May 2007 | pmid = 17483322 | doi = 10.1158/0008-5472.CAN-06-4705 | doi-access = free | url = https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1A_from_Phosphorylation_and_Activation_of_Cell_Division_Cycle_Associated_8_by_Aurora_Kinase_B_Plays_a_Significant_Role_in_Human_Lung_Carcinogenesis/22370493/1/files/39815568.pdf }}
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External links
- {{UCSC gene info|CDCA8}}
{{gene-1-stub}}