CDH11

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. The mammalian CDH-11 homologues are termed calsyntenin.{{cite journal | vauthors = Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P | title = Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain | journal = Mol. Cell. Neurosci. | volume = 17 | issue = 1 | pages = 151–66 | year = 2001 | pmid = 11161476 | doi = 10.1006/mcne.2000.0937 | s2cid = 30856590 }}

CDH11 is overexpressed in 15% of breast cancers and seems essential to tumour progression in some other cancer types.{{cite web |url=http://www.genengnews.com/gen-news-highlights/new-therapeutic-approach-could-target-both-cancer-and-arthritis/81249121/ |title=New Therapeutic Approach Could Target Both Cancer and Arthritis |date=15 Nov 2013 }}{{cite journal | vauthors = Assefnia S, Dakshanamurthy S, Guidry Auvil JM, Hampel C, Anastasiadis PZ, Kallakury B, Uren A, Foley DW, Brown ML, Shapiro L, Brenner M, Haigh D, Byers SW | title = Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. | journal = Oncotarget | volume = 5 | issue = 6 | pages = 1458–74 | date = Mar 2014 | pmid = 24681547 | doi=10.18632/oncotarget.1538 | pmc=4039224}}

Arthritis drug celecoxib binds to CDH11.

CDH11 has been shown to interact with CDH2.{{cite journal | vauthors = Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW | title = A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells | journal = J. Cell Sci. | volume = 116 | issue = Pt 24 | pages = 4985–95 | date = Dec 2003 | pmid = 14625392 | doi = 10.1242/jcs.00815 | doi-access = free }}

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• {{cite journal | vauthors = Suzuki S, Sano K, Tanihara H | title = Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. | journal = Cell Regul. | volume = 2 | issue = 4 | pages = 261–70 | year = 1991 | pmid = 2059658 | pmc = 361775 | doi = 10.1091/mbc.2.4.261 }}
• {{cite journal | vauthors = Tanihara H, Sano K, Heimark RL, St John T, Suzuki S | title = Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. | journal = Cell Adhes. Commun. | volume = 2 | issue = 1 | pages = 15–26 | year = 1995 | pmid = 7982033 | doi = 10.3109/15419069409014199 }}
• {{cite journal | vauthors = Okazaki M, Takeshita S, Kawai S, Kikuno R, Tsujimura A, Kudo A, Amann E | title = Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. | journal = J. Biol. Chem. | volume = 269 | issue = 16 | pages = 12092–8 | year = 1994 | doi = 10.1016/S0021-9258(17)32685-6 | pmid = 8163513 | doi-access = free }}
• {{cite journal | vauthors = Getsios S, Chen GT, Stephenson MD, Leclerc P, Blaschuk OW, MacCalman CD | title = Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium. | journal = Dev. Dyn. | volume = 211 | issue = 3 | pages = 238–47 | year = 1998 | pmid = 9520111 | doi = 10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I | s2cid = 43022919 | doi-access = }}
• {{cite journal | vauthors = Pishvaian MJ, Feltes CM, Thompson P, Bussemakers MJ, Schalken JA, Byers SW | title = Cadherin-11 is expressed in invasive breast cancer cell lines. | journal = Cancer Res. | volume = 59 | issue = 4 | pages = 947–52 | year = 1999 | pmid = 10029089 }}
• {{cite journal | vauthors = Kawaguchi J, Takeshita S, Kashima T, Imai T, Machinami R, Kudo A | title = Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11. | journal = J. Bone Miner. Res. | volume = 14 | issue = 5 | pages = 764–75 | year = 1999 | pmid = 10320525 | doi = 10.1359/jbmr.1999.14.5.764 | s2cid = 12829659 | doi-access = free }}
• {{cite journal | vauthors = Braungart E, Schumacher C, Hartmann E, Nekarda H, Becker KF, Höfler H, Atkinson MJ | title = Functional loss of E-cadherin and cadherin-11 alleles on chromosome 16q22 in colonic cancer. | journal = J. Pathol. | volume = 187 | issue = 5 | pages = 530–4 | year = 2000 | pmid = 10398117 | doi = 10.1002/(SICI)1096-9896(199904)187:5<530::AID-PATH293>3.0.CO;2-C | s2cid = 22384331 }}
• {{cite journal | vauthors = Kashima T, Kawaguchi J, Takeshita S, Kuroda M, Takanashi M, Horiuchi H, Imamura T, Ishikawa Y, Ishida T, Mori S, Machinami R, Kudo A | title = Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis. | journal = Am. J. Pathol. | volume = 155 | issue = 5 | pages = 1549–55 | year = 1999 | pmid = 10550312 | pmc = 1866957 | doi = 10.1016/S0002-9440(10)65471-5 }}
• {{cite journal | vauthors = Lecanda F, Cheng SL, Shin CS, Davidson MK, Warlow P, Avioli LV, Civitelli R | title = Differential regulation of cadherins by dexamethasone in human osteoblastic cells. | journal = J. Cell. Biochem. | volume = 77 | issue = 3 | pages = 499–506 | year = 2000 | pmid = 10760957 | doi = 10.1002/(SICI)1097-4644(20000601)77:3<499::AID-JCB14>3.0.CO;2-0 | s2cid = 13331343 }}
• {{cite journal | vauthors = Braungart E, Hartman E, Bechler K, Höfler H, Atkinson MJ | title = The intracellular domain of cadherin-11 is not required for the induction of cell aggregation, adhesion or gap-junction formation. | journal = Cell Commun. Adhes. | volume = 8 | issue = 1 | pages = 15–27 | year = 2002 | pmid = 11775026 | doi = 10.3109/15419060109080704 | s2cid = 23322445 }}
• {{cite journal | vauthors = Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW | title = A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. | journal = J. Cell Sci. | volume = 116 | issue = Pt 24 | pages = 4985–95 | year = 2004 | pmid = 14625392 | doi = 10.1242/jcs.00815 | doi-access = free }}
• {{cite journal | vauthors = Morimoto AM, Tan N, West K, McArthur G, Toner GC, Manning WC, Smolich BD, Cherrington JM | title = Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor. | journal = Oncogene | volume = 23 | issue = 8 | pages = 1618–26 | year = 2004 | pmid = 14985702 | doi = 10.1038/sj.onc.1207268 | s2cid = 23251484 | doi-access = }}
• {{cite journal | vauthors = Marchong MN, Chen D, Corson TW, Lee C, Harmandayan M, Bowles E, Chen N, Gallie BL | title = Minimal 16q genomic loss implicates cadherin-11 in retinoblastoma. | journal = Mol. Cancer Res. | volume = 2 | issue = 9 | pages = 495–503 | year = 2005 | doi = 10.1158/1541-7786.495.2.9 | pmid = 15383628 | s2cid = 24674595 | doi-access = free }}
• {{cite journal | vauthors = Oliveira AM, Perez-Atayde AR, Inwards CY, Medeiros F, Derr V, Hsi BL, Gebhardt MC, Rosenberg AE, Fletcher JA | title = USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. | journal = Am. J. Pathol. | volume = 165 | issue = 5 | pages = 1773–80 | year = 2004 | pmid = 15509545 | pmc = 3278819 | doi = 10.1016/S0002-9440(10)63432-3 }}
• {{cite journal | vauthors = Kiener HP, Brenner MB | title = Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion. | journal = Arthritis Research & Therapy | volume = 7 | issue = 2 | pages = 49–54 | year = 2005 | pmid = 15743489 | pmc = 1065331 | doi = 10.1186/ar1495 | doi-access = free }}
• {{cite journal | vauthors = Kiener HP, Lee DM, Agarwal SK, Brenner MB | title = Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro. | journal = Am. J. Pathol. | volume = 168 | issue = 5 | pages = 1486–99 | year = 2006 | pmid = 16651616 | pmc = 1606584 | doi = 10.2353/ajpath.2006.050999 }}

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• {{UCSC genome browser|CDH11}}
• {{UCSC gene details|CDH11}}

{{PDB Gallery|geneid=1009}}

{{Cell adhesion molecules}}

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