CDH15

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.

CDH15 has been shown to interact with ARVCF.{{cite journal | vauthors = Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A | title = The armadillo repeat region targets ARVCF to cadherin-based cellular junctions | journal = J. Cell Sci. | volume = 113 | issue = 22 | pages = 4121–35 | date = November 2000 | doi = 10.1242/jcs.113.22.4121 | pmid = 11058098 }}

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• {{cite journal | vauthors = Donalies M, Cramer M, Ringwald M, Starzinski-Powitz A | title = Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 88 | issue = 18 | pages = 8024–8 | year = 1991 | pmid = 1840697 | pmc = 52438 | doi = 10.1073/pnas.88.18.8024 | bibcode = 1991PNAS...88.8024D | doi-access = free }}
• {{cite journal | vauthors = Bornemann A, Schmalbruch H | title = Immunocytochemistry of M-cadherin in mature and regenerating rat muscle. | journal = Anat. Rec. | volume = 239 | issue = 2 | pages = 119–25 | year = 1994 | pmid = 8059975 | doi = 10.1002/ar.1092390202 | s2cid = 43526913 }}
• {{cite journal | vauthors = Shibata T, Shimoyama Y, Gotoh M, Hirohashi S | title = Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. | journal = J. Biol. Chem. | volume = 272 | issue = 8 | pages = 5236–40 | year = 1997 | pmid = 9030594 | doi = 10.1074/jbc.272.8.5236 | doi-access = free }}
• {{cite journal | vauthors = Kuch C, Winnekendonk D, Butz S, Unvericht U, Kemler R, Starzinski-Powitz A | title = M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells. | journal = Exp. Cell Res. | volume = 232 | issue = 2 | pages = 331–8 | year = 1997 | pmid = 9168809 | doi = 10.1006/excr.1997.3519 }}
• {{cite journal | vauthors = Shimoyama Y, Shibata T, Kitajima M, Hirohashi S | title = Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin. | journal = J. Biol. Chem. | volume = 273 | issue = 16 | pages = 10011–8 | year = 1998 | pmid = 9545347 | doi = 10.1074/jbc.273.16.10011 | doi-access = free }}
• {{cite journal | vauthors = Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF | title = Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. | journal = Genomics | volume = 49 | issue = 3 | pages = 467–71 | year = 1998 | pmid = 9615235 | doi = 10.1006/geno.1998.5281 }}
• {{cite journal | vauthors = Shimoyama Y, Tsujimoto G, Kitajima M, Natori M | title = Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. | journal = Biochem. J. | volume = 349 | issue = Pt 1 | pages = 159–67 | year = 2001 | pmid = 10861224 | pmc = 1221133 | doi = 10.1042/0264-6021:3490159 }}
• {{cite journal | vauthors = Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A | title = The armadillo repeat region targets ARVCF to cadherin-based cellular junctions. | journal = J. Cell Sci. | volume = 113 | issue = 22 | pages = 4121–35 | year = 2001 | doi = 10.1242/jcs.113.22.4121 | pmid = 11058098 }}
• {{cite journal | vauthors = Meigs TE, Fields TA, McKee DD, Casey PJ | title = Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 2 | pages = 519–24 | year = 2001 | pmid = 11136230 | pmc = 14619 | doi = 10.1073/pnas.021350998 | doi-access = free }}
• {{cite journal | vauthors = Hollnagel A, Grund C, Franke WW, Arnold HH | title = The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration. | journal = Mol. Cell. Biol. | volume = 22 | issue = 13 | pages = 4760–70 | year = 2002 | pmid = 12052883 | pmc = 133893 | doi = 10.1128/MCB.22.13.4760-4770.2002 }}
• {{cite journal | vauthors = Kang JS, Feinleib JL, Knox S, Ketteringham MA, Krauss RS | title = Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 7 | pages = 3989–94 | year = 2003 | pmid = 12634428 | pmc = 153035 | doi = 10.1073/pnas.0736565100 | bibcode = 2003PNAS..100.3989K | doi-access = free }}

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• {{UCSC genome browser|CDH15}}
• {{UCSC gene details|CDH15}}
• {{UCSC gene info|CDH3}}

{{Cell adhesion molecules}}

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