CDH17

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.{{cite journal | vauthors = Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF | title = Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity | journal = Genomics | volume = 49 | issue = 3 | pages = 467–71 |date=Aug 1998 | pmid = 9615235 | doi = 10.1006/geno.1998.5281 }}{{cite journal | vauthors = Chalmers IJ, Hofler H, Atkinson MJ | title = Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma | journal = Genomics | volume = 57 | issue = 1 | pages = 160–3 |date=Jun 1999 | pmid = 10191097 | doi = 10.1006/geno.1998.5717 }}{{cite web | title = Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1015}}

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.{{cite web | title = Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1015}}

References

{{cite journal | vauthors=Gessner R, Tauber R |title=Intestinal cell adhesion molecules. Liver-intestine cadherin. |journal=Ann. N. Y. Acad. Sci. |volume=915 |pages= 136–43 |year= 2001 |pmid= 11193569 |doi=10.1111/j.1749-6632.2000.tb05236.x |s2cid=27317315 }}
{{cite journal | author=Gilston A |title=Reducing the hazard of disconnected tubes. |journal=Anaesthesia |volume=32 |issue= 9 |pages= 922 |year= 1978 |pmid= 603017 |doi=10.1111/j.1365-2044.1977.tb10133.x |s2cid=31703359 |doi-access=free }}
{{cite journal | vauthors=Dantzig AH, Hoskins JA, Tabas LB |title=Association of intestinal peptide transport with a protein related to the cadherin superfamily. |journal=Science |volume=264 |issue= 5157 |pages= 430–3 |year= 1994 |pmid= 8153632 |doi=10.1126/science.8153632 |bibcode=1994Sci...264..430D |display-authors=etal}}
{{cite journal | vauthors=Suzuki Y, Tsunoda T, Sese J |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.gr-1640r| pmc=311086 |display-authors=etal}}
{{cite journal | vauthors=Grötzinger C, Kneifel J, Patschan D |title=LI-cadherin: a marker of gastric metaplasia and neoplasia. |journal=Gut |volume=49 |issue= 1 |pages= 73–81 |year= 2001 |pmid= 11413113 |doi=10.1136/gut.49.1.73 | pmc=1728355 |display-authors=etal}}
{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Takamura M, Sakamoto M, Ino Y |title=Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas. |journal=Cancer Sci. |volume=94 |issue= 5 |pages= 425–30 |year= 2003 |pmid= 12824888 |doi=10.1111/j.1349-7006.2003.tb01459.x |s2cid=25229564 |display-authors=etal|doi-access=free |pmc=11160223 }}
{{cite journal | vauthors=Wendeler MW, Praus M, Jung R |title=Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin. |journal=Exp. Cell Res. |volume=294 |issue= 2 |pages= 345–55 |year= 2004 |pmid= 15023525 |doi= 10.1016/j.yexcr.2003.11.022 |display-authors=etal}}
{{cite journal | vauthors=Ko S, Chu KM, Luk JM |title=Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 2 |pages= 562–8 |year= 2004 |pmid= 15178443 |doi= 10.1016/j.bbrc.2004.04.197 |display-authors=etal}}
{{cite journal | vauthors=Takamura M, Ichida T, Matsuda Y |title=Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. |journal=Cancer Lett. |volume=212 |issue= 2 |pages= 253–9 |year= 2004 |pmid= 15279905 |doi= 10.1016/j.canlet.2004.03.016 |display-authors=etal}}
{{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Wang XQ, Luk JM, Leung PP |title=Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma. |journal=Clin. Cancer Res. |volume=11 |issue= 2 Pt 1 |pages= 483–9 |year= 2005 |doi=10.1158/1078-0432.483.11.2 |pmid= 15701831 |display-authors=etal|doi-access=free }}
{{cite journal | vauthors=Wang XQ, Luk JM, Garcia-Barcelo M |title=Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma. |journal=Clin. Cancer Res. |volume=12 |issue= 17 |pages= 5248–52 |year= 2007 |pmid= 16951245 |doi= 10.1158/1078-0432.CCR-06-0558 |display-authors=etal|doi-access= |s2cid=22423581 }}

External links

{{UCSC genome browser|CDH17}}
{{UCSC gene details|CDH17}}
{{UCSC gene info|CDH16}}

CDH17

References

Further reading

External links