CDKL2
{{Short description|Protein-coding gene in humans}}
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Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.{{cite journal | vauthors = Taglienti CA, Wysk M, Davis RJ | title = Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE | journal = Oncogene | volume = 13 | issue = 12 | pages = 2563–2574 | date = Feb 1997 | pmid = 9000130 }}{{cite web | title = Entrez Gene: CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8999 }}
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.
References
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Further reading
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- {{cite journal | vauthors = Marracci GH, Marquardt WE, Strehlow A, McKeon GP, Gross J, Buck DC, Kozell LB, Bourdette DN | title = Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck) | journal = Biochemical and Biophysical Research Communications | volume = 344 | issue = 3 | pages = 963–971 | date = Jun 2006 | pmid = 16631599 | doi = 10.1016/j.bbrc.2006.03.172 }}
- {{cite journal | vauthors = Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC | title = Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling | journal = Nature Structural & Molecular Biology | volume = 11 | issue = 11 | pages = 1060–1067 | date = Nov 2004 | pmid = 15502848 | doi = 10.1038/nsmb847 | s2cid = 6869429 }}
- {{cite journal | vauthors = Tao J, Esch H, Hagedorn-Greiwe M, Hoffmann K, Moser B, Raynaud M, Sperner J, Fryns JP, Schwinger E, Gecz J, Ropers HH, Kalscheuer VM | title = Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation | journal = American Journal of Human Genetics | volume = 75 | issue = 6 | pages = 1149–1154 | date = Dec 2004 | pmid = 15499549 | pmc = 1182152 | doi = 10.1086/426460 }}
- {{cite journal | vauthors = ((Sanger Center)), ((Genome Sequencing Center)) | title = Toward a complete human genome sequence | journal = Genome Research | volume = 8 | issue = 11 | pages = 1097–1108 | date = Nov 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 | doi-access = free }}
- {{cite journal | vauthors = Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC | title = Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors | journal = Journal of Biological Chemistry | volume = 270 | issue = 16 | pages = 9115–9120 | date = Apr 1995 | pmid = 7721825 | doi = 10.1074/jbc.270.16.9115 | doi-access = free }}
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External links
- {{UCSC gene info|CDKL2}}
- {{PDBe-KB2|Q92772|Cyclin-dependent kinase-like 2}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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