CDS1 (gene)

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin. and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (CDS2) to 20p13.

{{reflist|refs=

{{cite thesis | vauthors = Nowicki M | title = Characterization of the Cardiolipin Synthase from Arabidopsis thaliana | degree = Ph.D. Thesis | publisher = RWTH-Aachen University | year = 2006 | url = http://darwin.bth.rwth-aachen.de/opus/volltexte/2006/1629/ | access-date = 2011-07-11 | archive-url = https://web.archive.org/web/20111005093127/http://darwin.bth.rwth-aachen.de/opus/volltexte/2006/1629/ | archive-date = 2011-10-05 | url-status = dead }}

{{cite web | title = Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1040}}

{{cite journal | vauthors = Nowicki M, Müller F, Frentzen M | title = Cardiolipin synthase of Arabidopsis thaliana | journal = FEBS Letters | volume = 579 | issue = 10 | pages = 2161–5 | date = April 2005 | pmid = 15811335 | doi = 10.1016/j.febslet.2005.03.007 | s2cid = 21937549 | doi-access = free }}

{{cite journal | vauthors = Weeks R, Dowhan W, Shen H, Balantac N, Meengs B, Nudelman E, Leung DW | title = Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA | journal = DNA and Cell Biology | volume = 16 | issue = 3 | pages = 281–9 | date = March 1997 | pmid = 9115637 | doi = 10.1089/dna.1997.16.281 }}

{{cite journal | vauthors = Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM | title = Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes | journal = Genomics | volume = 54 | issue = 1 | pages = 140–4 | date = November 1998 | pmid = 9806839 | doi = 10.1006/geno.1998.5547 }}

}}

{{refbegin | 2}}

• {{cite journal | vauthors = Liu Y, Virshup DM, White RL, Hsu LC | title = Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha | journal = Cancer Research | volume = 62 | issue = 22 | pages = 6357–61 | date = November 2002 | pmid = 12438214 }}
• {{cite journal | vauthors = Volta M, Bulfone A, Gattuso C, Rossi E, Mariani M, Consalez GG, Zuffardi O, Ballabio A, Banfi S, Franco B | display-authors = 6 | title = Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene | journal = Genomics | volume = 55 | issue = 1 | pages = 68–77 | date = January 1999 | pmid = 9889000 | doi = 10.1006/geno.1998.5610 }}
• {{cite journal | vauthors = Lykidis A, Jackson PD, Rock CO, Jackowski S | title = The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 33402–9 | date = December 1997 | pmid = 9407135 | doi = 10.1074/jbc.272.52.33402 | doi-access = free }}
• {{cite journal | vauthors = Heacock AM, Uhler MD, Agranoff BW | title = Cloning of CDP-diacylglycerol synthase from a human neuronal cell line | journal = Journal of Neurochemistry | volume = 67 | issue = 5 | pages = 2200–3 | date = November 1996 | pmid = 8863531 | doi = 10.1046/j.1471-4159.1996.67052200.x | url = https://deepblue.lib.umich.edu/bitstream/2027.42/65959/1/j.1471-4159.1996.67052200.x.pdf | s2cid = 2805319 | hdl = 2027.42/65959 | hdl-access = free }}

{{refend}}

• {{UCSC gene info|CDS1}}

{{Kinases}}

{{Enzymes}}

{{Portal bar|Biology|border=no}}

Category:EC 2.7.7

{{gene-4-stub}}