CEACAM5

In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer.{{cite journal | vauthors = Beauchemin N, Arabzadeh A | title = Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis | journal = Cancer and Metastasis Reviews | volume = 32 | issue = 3–4 | pages = 643–671 | date = December 2013 | pmid = 23903773 | doi = 10.1007/s10555-013-9444-6 | s2cid = 10344352 }}{{cite journal | vauthors = Zhang X, Han X, Zuo P, Zhang X, Xu H | title = CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration | journal = The Journal of International Medical Research | volume = 48 | issue = 9 | pages = 300060520959478 | date = September 2020 | pmid = 32993395 | pmc = 7536504 | doi = 10.1177/0300060520959478 }} Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells.{{cite journal | vauthors = Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP | title = Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule | journal = Cell | volume = 57 | issue = 2 | pages = 327–334 | date = April 1989 | pmid = 2702691 | doi = 10.1016/0092-8674(89)90970-7 | s2cid = 30740594 }} Also, it plays a significant role in the inhibition of differentiation {{cite journal | vauthors = Ilantzis C, DeMarte L, Screaton RA, Stanners CP | title = Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation | journal = Neoplasia | volume = 4 | issue = 2 | pages = 151–163 | date = 2002 | pmid = 11896570 | pmc = 1550325 | doi = 10.1038/sj.neo.7900201 }} and apoptosis {{cite journal | vauthors = Ordoñez C, Screaton RA, Ilantzis C, Stanners CP | title = Human carcinoembryonic antigen functions as a general inhibitor of anoikis | journal = Cancer Research | volume = 60 | issue = 13 | pages = 3419–3424 | date = July 2000 | pmid = 10910050 | url = https://pubmed.ncbi.nlm.nih.gov/10910050 }} in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells.{{cite journal | vauthors = Gisina A, Novikova S, Kim Y, Sidorov D, Bykasov S, Volchenko N, Kaprin A, Zgoda V, Yarygin K, Lupatov A | display-authors = 6 | title = CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells | journal = Cancer Biomarkers | volume = 32 | issue = 1 | pages = 85–98 | date = 2021-01-01 | pmid = 34092615 | doi = 10.3233/CBM-203187 | s2cid = 235359543 }} High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).{{Cite journal | vauthors = LaPointe N, Hertle N, Hsu SC, Kellis J, King N, Littrell J, Nguyen Q, Ren J, Srdanov MR, Tanna V, Thakrar S | display-authors = 6 |date=2021-05-20 |title=Validation of an immunohistochemical assay, CEACAM5 IHC 769, under development for use with the antibody-drug conjugate tusamitamab ravtansine (SAR408701). |journal=Journal of Clinical Oncology |language=en |volume=39 |issue=15_suppl |pages=e21030 |doi=10.1200/JCO.2021.39.15_suppl.e21030 | s2cid = 236398737 |issn=0732-183X}}{{cite journal | vauthors = Kim YJ, Li W, Zhelev DV, Mellors JW, Dimitrov DS, Baek DS | title = Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates | journal = Frontiers in Oncology | volume = 13 | pages = 1124039 | date = 2023-02-27 | pmid = 36923424 | pmc = 10010383 | doi = 10.3389/fonc.2023.1124039 | doi-access = free }}

• Cluster of differentiation

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• {{cite journal | vauthors = Willcocks TC, Craig IW | title = Characterization of the genomic organization of human carcinoembryonic antigen (CEA): comparison with other family members and sequence analysis of 5' controlling region | journal = Genomics | volume = 8 | issue = 3 | pages = 492–500 | date = November 1990 | pmid = 2286372 | doi = 10.1016/0888-7543(90)90036-T }}
• {{cite journal | vauthors = Barnett T, Zimmermann W | title = Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family | journal = Tumour Biology | volume = 11 | issue = 1–2 | pages = 59–63 | year = 1990 | pmid = 2309067 | doi = 10.1159/000217643 }}
• {{cite journal | vauthors = Schrewe H, Thompson J, Bona M, Hefta LJ, Maruya A, Hassauer M, Shively JE, von Kleist S, Zimmermann W | display-authors = 6 | title = Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression | journal = Molecular and Cellular Biology | volume = 10 | issue = 6 | pages = 2738–2748 | date = June 1990 | pmid = 2342461 | pmc = 360634 | doi = 10.1128/MCB.10.6.2738 }}
• {{cite journal | vauthors = Kamarck ME, Elting JJ, Hart JT, Goebel SJ, Rae PM, Nothdurft MA, Nedwin JJ, Barnett TR | display-authors = 6 | title = Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 84 | issue = 15 | pages = 5350–5354 | date = August 1987 | pmid = 2955415 | pmc = 298853 | doi = 10.1073/pnas.84.15.5350 | doi-access = free | bibcode = 1987PNAS...84.5350K }}
• {{cite journal | vauthors = Zimmermann W, Ortlieb B, Friedrich R, von Kleist S | title = Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 84 | issue = 9 | pages = 2960–2964 | date = May 1987 | pmid = 3033671 | pmc = 304780 | doi = 10.1073/pnas.84.9.2960 | doi-access = free | bibcode = 1987PNAS...84.2960Z }}
• {{cite journal | vauthors = Barnett T, Goebel SJ, Nothdurft MA, Elting JJ | title = Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains | journal = Genomics | volume = 3 | issue = 1 | pages = 59–66 | date = July 1988 | pmid = 3220478 | doi = 10.1016/0888-7543(88)90160-7 }}
• {{cite journal | vauthors = Zimmermann W, Weber B, Ortlieb B, Rudert F, Schempp W, Fiebig HH, Shively JE, von Kleist S, Thompson JA | display-authors = 6 | title = Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors | journal = Cancer Research | volume = 48 | issue = 9 | pages = 2550–2554 | date = May 1988 | pmid = 3356015 }}
• {{cite journal | vauthors = Beauchemin N, Benchimol S, Cournoyer D, Fuks A, Stanners CP | title = Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen | journal = Molecular and Cellular Biology | volume = 7 | issue = 9 | pages = 3221–3230 | date = September 1987 | pmid = 3670312 | pmc = 367958 | doi = 10.1128/MCB.7.9.3221 }}
• {{cite journal | vauthors = Oikawa S, Nakazato H, Kosaki G | title = Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence | journal = Biochemical and Biophysical Research Communications | volume = 142 | issue = 2 | pages = 511–518 | date = January 1987 | pmid = 3814146 | doi = 10.1016/0006-291X(87)90304-4 }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Hart SP, Ross JA, Ross K, Haslett C, Dransfield I | title = Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes | journal = Cell Death and Differentiation | volume = 7 | issue = 5 | pages = 493–503 | date = May 2000 | pmid = 10800083 | doi = 10.1038/sj.cdd.4400680 | doi-access = free }}
• {{cite journal | vauthors = Guignot J, Peiffer I, Bernet-Camard MF, Lublin DM, Carnoy C, Moseley SL, Servin AL | title = Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells | journal = Infection and Immunity | volume = 68 | issue = 6 | pages = 3554–3563 | date = June 2000 | pmid = 10816511 | pmc = 97642 | doi = 10.1128/IAI.68.6.3554-3563.2000 }}
• {{cite journal | vauthors = Boehm MK, Perkins SJ | title = Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23 | journal = FEBS Letters | volume = 475 | issue = 1 | pages = 11–16 | date = June 2000 | pmid = 10854848 | doi = 10.1016/S0014-5793(00)01612-4 | s2cid = 5765612 | doi-access = free }}
• {{cite journal | vauthors = Screaton RA, DeMarte L, Dráber P, Stanners CP | title = The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor | journal = The Journal of Cell Biology | volume = 150 | issue = 3 | pages = 613–626 | date = August 2000 | pmid = 10931872 | pmc = 2175204 | doi = 10.1083/jcb.150.3.613 }}
• {{cite journal | vauthors = Bajenova OV, Zimmer R, Stolper E, Salisbury-Rowswell J, Nanji A, Thomas P | title = Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 33 | pages = 31067–31073 | date = August 2001 | pmid = 11406629 | doi = 10.1074/jbc.M104093200 | doi-access = free }}
• {{cite journal | vauthors = Wirth T, Soeth E, Czubayko F, Juhl H | title = Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth | journal = Clinical & Experimental Metastasis | volume = 19 | issue = 2 | pages = 155–160 | year = 2002 | pmid = 11964079 | doi = 10.1023/A:1014566127493 | s2cid = 3138022 }}
• {{cite journal | vauthors = Louhimo J, Carpelan-Holmström M, Alfthan H, Stenman UH, Järvinen HJ, Haglund C | title = Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer | journal = International Journal of Cancer | volume = 101 | issue = 6 | pages = 545–548 | date = October 2002 | pmid = 12237895 | doi = 10.1002/ijc.90009 | s2cid = 7030523 | doi-access = free }}
• {{cite journal | vauthors = Hampton R, Walker M, Marshall J, Juhl H | title = Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells | journal = Oncogene | volume = 21 | issue = 51 | pages = 7817–7823 | date = November 2002 | pmid = 12420218 | doi = 10.1038/sj.onc.1205906 | doi-access = free }}

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• {{MeshName|CEACAM5+protein,+human}}
• {{UCSC gene info|CEACAM5}}
• [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P06731 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)

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{{PDB Gallery|geneid=1048}}

{{Clusters of differentiation}}

Category:Clusters of differentiation

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