CEBPD

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.{{cite web | title = Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1052}}

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.{{cite journal | vauthors = Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP | title = C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation | journal = Oncogene | volume = 24 | issue = 9 | pages = 1589–1597 | date = February 2005 | pmid = 15674331 | doi = 10.1038/sj.onc.1208393 | s2cid = 24347537 | doi-access = }}

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.{{cite journal | vauthors = Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA | title = CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 94 | issue = 1 | pages = 89–97 | date = January 2014 | pmid = 24247561 | doi = 10.1038/labinvest.2013.127 | doi-access = free }}

Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.{{cite journal | vauthors = Munkácsy G, Sztupinszki Z, Herman P, Bán B, Pénzváltó Z, Szarvas N, Győrffy B | title = Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments | journal = Molecular Therapy. Nucleic Acids | volume = 5 | issue = 9 | pages = e366 | date = September 2016 | pmid = 27673562 | pmc = 5056990 | doi = 10.1038/mtna.2016.66 }}

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.{{cite journal | vauthors = Choy L, Derynck R | title = Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function | journal = The Journal of Biological Chemistry | volume = 278 | issue = 11 | pages = 9609–9619 | date = March 2003 | pmid = 12524424 | doi = 10.1074/jbc.M212259200 | doi-access = free }}

• Ccaat-enhancer-binding proteins

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• {{cite journal | vauthors = Sladek FM, Darnell JE | title = Mechanisms of liver-specific gene expression | journal = Current Opinion in Genetics & Development | volume = 2 | issue = 2 | pages = 256–259 | date = April 1992 | pmid = 1638120 | doi = 10.1016/S0959-437X(05)80282-5 }}
• {{cite journal | vauthors = Kinoshita S, Akira S, Kishimoto T | title = A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 4 | pages = 1473–1476 | date = February 1992 | pmid = 1741402 | pmc = 48473 | doi = 10.1073/pnas.89.4.1473 | doi-access = free | bibcode = 1992PNAS...89.1473K }}
• {{cite journal | vauthors = Nagulapalli S, Pongubala JM, Atchison ML | title = Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3) | journal = Journal of Immunology | volume = 155 | issue = 9 | pages = 4330–4338 | date = November 1995 | pmid = 7594592 | doi = 10.4049/jimmunol.155.9.4330 | doi-access = free }}
• {{cite journal | vauthors = Wood S, Schertzer M, Yaremko ML | title = Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p | journal = Cytogenetics and Cell Genetics | volume = 70 | issue = 3–4 | pages = 188–191 | year = 1995 | pmid = 7789168 | doi = 10.1159/000134030 }}
• {{cite journal | vauthors = Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, Wells DE, Trapman J | title = The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization | journal = Genomics | volume = 16 | issue = 2 | pages = 520–523 | date = May 1993 | pmid = 8314590 | doi = 10.1006/geno.1993.1220 }}
• {{cite journal | vauthors = Chen PL, Riley DJ, Chen Y, Lee WH | title = Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs | journal = Genes & Development | volume = 10 | issue = 21 | pages = 2794–2804 | date = November 1996 | pmid = 8946919 | doi = 10.1101/gad.10.21.2794 | doi-access = free }}
• {{cite journal | vauthors = Xia C, Cheshire JK, Patel H, Woo P | title = Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes | journal = The International Journal of Biochemistry & Cell Biology | volume = 29 | issue = 12 | pages = 1525–1539 | date = December 1997 | pmid = 9570146 | doi = 10.1016/S1357-2725(97)00083-6 }}
• {{cite journal | vauthors = Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK | title = Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 6923–6928 | date = March 2002 | pmid = 11741938 | doi = 10.1074/jbc.M108075200 | doi-access = free }}
• {{cite journal | vauthors = Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, Sterneck E | title = C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2 | journal = Molecular and Cellular Probes | volume = 15 | issue = 6 | pages = 395–397 | date = December 2001 | pmid = 11851384 | doi = 10.1006/mcpr.2001.0377 | hdl-access = free | s2cid = 8215328 | hdl = 11382/3170 }}
• {{cite journal | vauthors = Gao H, Parkin S, Johnson PF, Schwartz RC | title = C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters | journal = The Journal of Biological Chemistry | volume = 277 | issue = 41 | pages = 38827–38837 | date = October 2002 | pmid = 12177065 | doi = 10.1074/jbc.M206224200 | doi-access = free }}
• {{cite journal | vauthors = Dearth LR, DeWille J | title = Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 13 | pages = 11246–11255 | date = March 2003 | pmid = 12554732 | doi = 10.1074/jbc.M207930200 | doi-access = free }}
• {{cite journal | vauthors = Milde-Langosch K, Löning T, Bamberger AM | title = Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins | journal = Breast Cancer Research and Treatment | volume = 79 | issue = 2 | pages = 175–185 | date = May 2003 | pmid = 12825852 | doi = 10.1023/A:1023929504884 | s2cid = 45020949 }}
• {{cite journal | vauthors = Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR | title = CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36959–36965 | date = September 2003 | pmid = 12857754 | doi = 10.1074/jbc.M303147200 | doi-access = free }}
• {{cite journal | vauthors = Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM | title = Molecular responses of human muscle to eccentric exercise | journal = Journal of Applied Physiology | volume = 95 | issue = 6 | pages = 2485–2494 | date = December 2003 | pmid = 12937035 | doi = 10.1152/japplphysiol.01161.2002 | s2cid = 9817319 }}
• {{cite journal | vauthors = Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J | title = CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease | journal = Neurobiology of Aging | volume = 25 | issue = 8 | pages = 991–999 | date = September 2004 | pmid = 15212823 | doi = 10.1016/j.neurobiolaging.2003.10.016 | s2cid = 54232508 }}
• {{cite journal | vauthors = Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW | title = CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control | journal = Journal of Cellular Biochemistry | volume = 93 | issue = 4 | pages = 844–856 | date = November 2004 | pmid = 15389878 | doi = 10.1002/jcb.20224 | s2cid = 31572695 }}

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• {{UCSC gene info|CEBPD}}
• {{MeshName|CEBPD+protein,+human}}

{{NLM content}}

{{Transcription factors|g1}}

{{DEFAULTSORT:Cebpd}}

Category:Transcription factors

{{Membrane-protein-stub}}