CELSR1

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin G-like domains in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.

• Flamingo (protein)

{{reflist}}

• {{UCSC gene info|CELSR1}}
• {{UCSC gene info|ME2}}

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• {{cite journal | vauthors=Nollet F, Kools P, van Roy F |title=Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 551–72 |year= 2000 |pmid= 10835267 |doi= 10.1006/jmbi.2000.3777 }}
• {{cite journal | vauthors=Wu Q, Maniatis T |title=A striking organization of a large family of human neural cadherin-like cell adhesion genes |journal=Cell |volume=97 |issue= 6 |pages= 779–90 |year= 1999 |pmid= 10380929 |doi=10.1016/S0092-8674(00)80789-8 |s2cid=6014717 |doi-access=free }}
• {{cite journal | vauthors=Dunham I, Shimizu N, Roe BA |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |bibcode=1999Natur.402..489D |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 | pmc=16203 |doi-access=free }}
• {{cite journal | author=Ghosh A |title=Dentritic{{sic|nolink=y}} growth: don't go says flamingo |journal=Neuron |volume=28 |issue= 1 |pages= 3–4 |year= 2000 |pmid= 11086974 |doi=10.1016/S0896-6273(00)00076-3 |s2cid=12982330 |doi-access=free }}
• {{cite journal | vauthors=Gross J, Grimm O, Ortega G |title=Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family |journal=Psychiatr. Genet. |volume=11 |issue= 4 |pages= 197–200 |year= 2002 |pmid= 11807409 |doi=10.1097/00041444-200112000-00003 |s2cid=32757646 |display-authors=etal}}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
• {{cite journal | vauthors=Georgieva L, Nikolov I, Poriazova N |title=Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia |journal=Psychiatr. Genet. |volume=13 |issue= 2 |pages= 103–6 |year= 2004 |pmid= 12782967 |doi= 10.1097/01.ypg.0000057486.14812.03 |s2cid=28084057 |display-authors=etal}}
• {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
• {{cite journal | vauthors=Carroll JS, Liu XS, Brodsky AS |title=Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1 |journal=Cell |volume=122 |issue= 1 |pages= 33–43 |year= 2005 |pmid= 16009131 |doi= 10.1016/j.cell.2005.05.008 |s2cid=16841542 |display-authors=etal|doi-access=free }}

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{{NLM content}}

{{G protein-coupled receptors}}

Category:Adhesion G protein-coupled receptors

Category:Chemokine receptors

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