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CEMIP

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene.{{cite web | title = Entrez Gene: KIAA1199 KIAA1199| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57214}} CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases.{{cite journal|last1=Yoshida|first1=H.|last2=Nagaoka|first2=A.|last3=Kusaka-Kikushima|first3=A.|last4=Tobiishi|first4=M.|last5=Kawabata|first5=K.|last6=Sayo|first6=T.|last7=Sakai|first7=S.|last8=Sugiyama|first8=Y.|last9=Enomoto|first9=H.|last10=Okada|first10=Y.|last11=Inoue|first11=S.|title=KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization|journal=Proceedings of the National Academy of Sciences|date=18 March 2013|volume=110|issue=14|pages=5612–5617|doi=10.1073/pnas.1215432110|pmid=23509262|pmc=3619336|bibcode=2013PNAS..110.5612Y |doi-access=free}} Such function has also been validated in mice.{{cite journal|last1=Yoshida|first1=Hiroyuki|last2=Nagaoka|first2=Aya|last3=Nakamura|first3=Sachiko|last4=Sugiyama|first4=Yoshinori|last5=Okada|first5=Yasunori|last6=Inoue|first6=Shintaro|title=Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization|journal=FEBS Open Bio|date=17 August 2013|volume=3|issue=1|pages=352–356|doi=10.1016/j.fob.2013.08.003|pmc=3821019|pmid=24251095}}

CEMIP is associated with nonsyndromic deafness,{{cite journal |vauthors=Abe S, Usami S, Nakamura Y | title = Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss | journal = J Hum Genet | volume = 48 | issue = 11 | pages = 564–70 |date=Nov 2003 | pmid = 14577002 | doi = 10.1007/s10038-003-0079-2 | doi-access = free }} as well as a variety of cancers.{{cite journal|last1=Zhang|first1=Yongsheng|last2=Jia|first2=Shuqin|last3=Jiang|first3=Wen|title=KIAA1199 and its biological role in human cancer and cancer cells (Review)|journal=Oncology Reports|date=20 February 2014|volume=31|issue=4|pages=1503–1508|doi=10.3892/or.2014.3038|pmid=24573670|doi-access=free}}

References

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Further reading

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  • {{cite journal |vauthors=Nagase T, Ishikawa K, Kikuno R, etal |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=10.1093/dnares/6.5.337 |doi-access=free }}
  • {{cite journal |vauthors=Wines ME, Lee L, Katari MS, etal |title=Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. |journal=Genomics |volume=72 |issue= 1 |pages= 88–98 |year= 2001 |pmid= 11247670 |doi= 10.1006/geno.2000.6466 }}
  • {{cite journal |vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
  • {{cite journal |vauthors=Abe S, Katagiri T, Saito-Hisaminato A, etal |title=Identification of CRYM as a Candidate Responsible for Nonsyndromic Deafness, through cDNA Microarray Analysis of Human Cochlear and Vestibular Tissues |journal=Am. J. Hum. Genet. |volume=72 |issue= 1 |pages= 73–82 |year= 2003 |pmid= 12471561 |doi=10.1086/345398 | pmc=420014 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Guo J, Cheng H, Zhao S, Yu L |title=GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases |journal=FEBS Lett. |volume=580 |issue= 2 |pages= 581–4 |year= 2006 |pmid= 16406369 |doi= 10.1016/j.febslet.2005.12.076 |doi-access= |s2cid=1013478 }}

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{{KIAA human genes}}

Category:Extracellular matrix remodeling enzymes

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