CENPI

{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

Centromere protein I is a protein that in humans is encoded by the CENPI gene.{{cite journal | vauthors = Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T | title = The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres | journal = Nature Cell Biology | volume = 8 | issue = 5 | pages = 446–57 | date = May 2006 | pmid = 16622420 | doi = 10.1038/ncb1396 | s2cid = 26974412 }}{{cite web | title = Entrez Gene: CENPI centromere protein I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2491}}

Function

The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis. CENPI is a target gene of the transcription factor E2F.{{cite journal | vauthors = Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH | title = CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer | journal = Oncotarget | volume = 8 | issue = 37 | pages = 62167–62182 | date = September 2017 | pmid = 28977935 | doi = 10.18632/oncotarget.19131 | pmc = 5617495 }} Additionally, CENPI expression is increased in breast cancer and this has been shown to cause chromosome instability in breast cancer cells.

References

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Further reading

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  • {{cite journal | vauthors = Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K | title = Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells | journal = Genes to Cells | volume = 11 | issue = 6 | pages = 673–84 | date = June 2006 | pmid = 16716197 | doi = 10.1111/j.1365-2443.2006.00969.x | doi-access = free }}
  • {{cite journal | vauthors = Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW | title = The human CENP-A centromeric nucleosome-associated complex | journal = Nature Cell Biology | volume = 8 | issue = 5 | pages = 458–69 | date = May 2006 | pmid = 16622419 | doi = 10.1038/ncb1397 | s2cid = 205286556 }}
  • {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = April 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}
  • {{cite journal | vauthors = Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K | title = Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase | journal = Genes to Cells | volume = 9 | issue = 2 | pages = 105–20 | date = February 2004 | pmid = 15009096 | doi = 10.1111/j.1365-2443.2004.00705.x | s2cid = 21813024 | doi-access = free }}
  • {{cite journal | vauthors = Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ | title = Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis | journal = Nature Cell Biology | volume = 5 | issue = 4 | pages = 341–5 | date = April 2003 | pmid = 12640463 | doi = 10.1038/ncb953 | s2cid = 33165992 }}
  • {{cite journal | vauthors = Roberts RG, Kendall E, Vetrie D, Bobrow M | title = Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene | journal = Genomics | volume = 37 | issue = 1 | pages = 122–4 | date = October 1996 | pmid = 8921378 | doi = 10.1006/geno.1996.0528 }}
  • {{cite journal | vauthors = Slegtenhorst-Eegdeman KE, Post M, Baarends WM, Themmen AP, Grootegoed JA | title = Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein | journal = Molecular and Cellular Endocrinology | volume = 108 | issue = 1–2 | pages = 115–24 | date = February 1995 | pmid = 7758824 | doi = 10.1016/0303-7207(94)03468-9 | hdl = 1765/64471 | s2cid = 11122437 | url = http://repub.eur.nl/pub/64471 | hdl-access = free }}
  • {{cite journal | vauthors = Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC | title = Sequence identification of 2,375 human brain genes | journal = Nature | volume = 355 | issue = 6361 | pages = 632–4 | date = February 1992 | pmid = 1538749 | doi = 10.1038/355632a0 | bibcode = 1992Natur.355..632A | s2cid = 4234345 }}

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