CENPM

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.{{cite journal | vauthors = Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T | title = The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres | journal = Nature Cell Biology | volume = 8 | issue = 5 | pages = 446–57 | date = May 2006 | pmid = 16622420 | doi = 10.1038/ncb1396 | s2cid = 26974412 }}{{cite journal | vauthors = Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW | title = The human CENP-A centromeric nucleosome-associated complex | journal = Nature Cell Biology | volume = 8 | issue = 5 | pages = 458–69 | date = May 2006 | pmid = 16622419 | doi = 10.1038/ncb1397 | s2cid = 205286556 }}{{cite web | title = Entrez Gene: CENPM centromere protein M| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79019}}

An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells.{{cite journal | vauthors = Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH | title = The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL | journal = Blood | volume = 107 | issue = 9 | pages = 3779–86 | year = 2006 | pmid = 16391015 | pmc = 1895781 | doi = 10.1182/blood-2005-08-3501 }}{{cite journal | vauthors = Bierie B, Edwin M, Melenhorst JJ, Hennighausen L | title = The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells | journal = Gene Expression Patterns | volume = 4 | issue = 4 | pages = 389–95 | date = July 2004 | pmid = 15183305 | doi = 10.1016/j.modgep.2004.01.008 }} Centromere protein M is involved in centromere assembly and immune response.{{cite journal | vauthors = Huang H, Deng H, Yang Y, Tang Z, Yang S, Mu Y, Cui W, Yuan J, Wu Z, Li K | title = Molecular characterization and association analysis of porcine PANE1 gene | journal = Molecular Biology Reports | volume = 37 | issue = 5 | pages = 2571–7 | year = 2010 | pmid = 19711193 | doi = 10.1007/s11033-009-9775-0 | s2cid = 20345149 }}