CENPO
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Centromere protein O is a protein that in humans is encoded by the CENPO gene.{{cite journal | vauthors = Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T | title = The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres | journal = Nat Cell Biol | volume = 8 | issue = 5 | pages = 446–57 |date=May 2006 | pmid = 16622420 | doi = 10.1038/ncb1396 | s2cid = 26974412 }}{{cite journal | vauthors = Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW | title = The human CENP-A centromeric nucleosome-associated complex | journal = Nat Cell Biol | volume = 8 | issue = 5 | pages = 458–69 |date=May 2006 | pmid = 16622419 | doi = 10.1038/ncb1397 | s2cid = 205286556 }}{{cite web | title = Entrez Gene: CENPO centromere protein O| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79172}} CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced. {{Cite journal|last1=Hewitt|first1=Chelsee A.|last2=Ling|first2=King-Hwa|last3=Merson|first3=Tobias D.|last4=Simpson|first4=Ken M.|last5=Ritchie|first5=Matthew E.|last6=King|first6=Sarah L.|last7=Pritchard|first7=Melanie A.|last8=Smyth|first8=Gordon K.|last9=Thomas|first9=Tim|date=2010-07-16|title=Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome|journal=PLOS ONE|volume=5|issue=7|pages=e11561|doi=10.1371/journal.pone.0011561|issn=1932-6203|pmc=2905390|pmid=20661276|bibcode=2010PLoSO...511561H |doi-access=free}}
References
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External links
- {{UCSC gene info|CENPO}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Obuse C, Yang H, Nozaki N |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105–20 |year= 2004 |pmid= 15009096 |doi=10.1111/j.1365-2443.2004.00705.x |s2cid=21813024 |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |display-authors=etal|doi-access=free }}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
- {{cite journal | vauthors=Izuta H, Ikeno M, Suzuki N |title=Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. |journal=Genes Cells |volume=11 |issue= 6 |pages= 673–84 |year= 2006 |pmid= 16716197 |doi= 10.1111/j.1365-2443.2006.00969.x |s2cid=45931410 |display-authors=etal|doi-access=free }}
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{{Chromosome genetics}}
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