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CEP135

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene.{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 3 | pages = 169–76 |date=Dec 1998 | pmid = 9734811 | doi =10.1093/dnares/5.3.169 | doi-access = free }}{{cite journal | vauthors = Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M | title = Proteomic characterization of the human centrosome by protein correlation profiling | journal = Nature | volume = 426 | issue = 6966 | pages = 570–4 |date=Dec 2003 | pmid = 14654843 | doi = 10.1038/nature02166 | bibcode = 2003Natur.426..570A | s2cid = 4427303 }}{{cite web | title = Entrez Gene: CEP135 centrosomal protein 135kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9662}}

It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material.{{cite journal | vauthors = Ohta T, Essner R, Ryu JH, Palazzo RE, Uetake Y, Kuriyama R | title = Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells | journal = J. Cell Biol. | volume = 156 | issue = 1 | pages = 87–99 |date=January 2002 | pmid = 11781336 | pmc = 2173569 | doi = 10.1083/jcb.200108088 }} CEP135 is required for the centriolar localization of CEP250.{{cite journal | vauthors = Kim K, Lee S, Chang J, Rhee K | title = A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization | journal = Exp. Cell Res. | volume = 314 | issue = 20 | pages = 3692–700 |date=December 2008 | pmid = 18851962 | doi = 10.1016/j.yexcr.2008.09.016 }}

References

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External links

  • {{UCSC gene info|CEP135}}
  • [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q66GS9 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 135 kDa

Further reading

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  • {{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
  • {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Colland F, Jacq X, Trouplin V |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |display-authors=etal}}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}

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{{centrosome}}

{{gene-4-stub}}

Category:Centrosome