CEP164
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene.{{cite web | title = Entrez Gene: centrosomal protein 164kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22897}}{{cite journal |vauthors=Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M | title = Proteomic characterization of the human centrosome by protein correlation profiling | journal = Nature | volume = 426 | issue = 6966 | pages = 570–4 |date=December 2003 | pmid = 14654843 | doi = 10.1038/nature02166 | bibcode = 2003Natur.426..570A | s2cid = 4427303 }}
Its function appears two be twofold: CEP164 is required for primary cilium formation.{{Cite journal
| doi = 10.1083/jcb.200707181
| pmc = 2064767
| title = Cep164, a novel centriole appendage protein required for primary cilium formation
| pmid = 17954613
| year = 2007
| last1 = Graser | first1 = S.
| last2 = Stierhof | first2 = Y. -D.
| last3 = Lavoie | first3 = S. B.
| last4 = Gassner | first4 = O. S.
| last5 = Lamla | first5 = S.
| last6 = Le Clech | first6 = M.
| last7 = Nigg | first7 = E. A.
| journal = The Journal of Cell Biology
| volume = 179
| issue = 2
| pages = 321–30
}} Furthermore, it is an important component in the response to DNA damage by UV light.{{Cite journal
| doi = 10.1101/gad.1627708
| pmc = 2259029
| title = Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1
| pmid = 18283122
| year = 2008
| last1 = Sivasubramaniam | first1 = S.
| last2 = Sun | first2 = X.
| last3 = Pan | first3 = Y. -R.
| last4 = Wang | first4 = S.
| last5 = Lee | first5 = E. Y. -H. P. |author5-link=Eva Y.-H. P. Lee
| journal = Genes & Development
| volume = 22
| issue = 5
| pages = 587–600
| pmid = 19197159
| year = 2009
| last1 = Pan
| first1 = YR
| last2 = Lee
| first2 = EY
| title = UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity
| volume = 8
| issue = 4
| pages = 655–64
| journal = Cell Cycle
| doi=10.4161/cc.8.4.7844
| doi-access = free
}}
References
{{reflist}}
External links
- {{UCSC gene info|CEP164}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Graser S, Stierhof YD, Lavoie SB |title=Cep164, a novel centriole appendage protein required for primary cilium formation |journal=J. Cell Biol. |volume=179 |issue= 2 |pages= 321–30 |year= 2007 |pmid= 17954613 |pmc=2064767 |doi= 10.1083/jcb.200707181 |display-authors=etal}}
- {{cite journal |vauthors=Golsteyn RM, Mundt KE, Fry AM, Nigg EA |title=Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function |journal=J. Cell Biol. |volume=129 |issue= 6 |pages= 1617–28 |year= 1995 |pmid= 7790358 |pmc=2291169 |doi=10.1083/jcb.129.6.1617 }}
- {{cite journal |vauthors=Casenghi M, Meraldi P, Weinhart U |title=Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation |journal=Dev. Cell |volume=5 |issue= 1 |pages= 113–25 |year= 2003 |pmid= 12852856 |doi=10.1016/S1534-5807(03)00193-X |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Mayor T, Stierhof YD, Tanaka K |title=The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 837–46 |year= 2000 |pmid= 11076968 |pmc=2169446 |doi=10.1083/jcb.151.4.837 |display-authors=etal}}
- {{cite journal |vauthors=Sivasubramaniam S, Sun X, Pan YR |title=Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1 |journal=Genes Dev. |volume=22 |issue= 5 |pages= 587–600 |year= 2008 |pmid= 18283122 |pmc=2259029 |doi= 10.1101/gad.1627708 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
- {{cite journal |vauthors=Petretti C, Savoian M, Montembault E |title=The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation |journal=EMBO Rep. |volume=7 |issue= 4 |pages= 418–24 |year= 2006 |pmid= 16462731 |pmc=1456919 |doi= 10.1038/sj.embor.7400639 |display-authors=etal}}
- {{cite journal |vauthors=Zick A, Onn I, Bezalel R |title=Assigning functions to genes: identification of S-phase expressed genes in Leishmania major based on post-transcriptional control elements |journal=Nucleic Acids Res. |volume=33 |issue= 13 |pages= 4235–42 |year= 2005 |pmid= 16052032 |pmc=1181863 |doi= 10.1093/nar/gki742 |display-authors=etal}}
- {{cite journal |vauthors=Pan YR, Lee EY |title=UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity |journal=Cell Cycle |volume=8 |issue= 4 |pages= 655–64 |year= 2009 |pmid= 19197159 |doi=10.4161/cc.8.4.7844 |doi-access=free }}
- {{cite journal |vauthors=Takahashi M, Yamagiwa A, Nishimura T |title=Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex |journal=Mol. Biol. Cell |volume=13 |issue= 9 |pages= 3235–45 |year= 2002 |pmid= 12221128 |pmc=124155 |doi= 10.1091/mbc.E02-02-0112 |display-authors=etal}}
{{refend}}
{{centrosome}}
{{gene-11-stub}}