CEP192

{{Short description|Protein-coding gene in the species Homo sapiens}}

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene.{{cite web | title = Entrez Gene: centrosomal protein 192kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55125}}{{cite journal |vauthors=Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M | title = Proteomic characterization of the human centrosome by protein correlation profiling | journal = Nature | volume = 426 | issue = 6966 | pages = 570–4 |date=December 2003 | pmid = 14654843 | doi = 10.1038/nature02166 | bibcode = 2003Natur.426..570A | s2cid = 4427303 }} It is the homolog of the C. elegans and D. melanogaster gene SPD-2.{{Cite journal

| doi = 10.1016/j.cub.2007.12.055

| pmid = 18207742

| year = 2008

| last1 = Zhu | first1 = F.

| last2 = Lawo | first2 = S.

| last3 = Bird | first3 = A.

| last4 = Pinchev | first4 = D.

| last5 = Ralph | first5 = A.

| last6 = Richter | first6 = C.

| last7 = Müller-Reichert | first7 = T.

| last8 = Kittler | first8 = R.

| last9 = Hyman | first9 = A.

| last10 = Pelletier | first10 = L.

| title = The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis

| volume = 18

| issue = 2

| pages = 136–141

| journal = Current Biology

| s2cid = 16159409

| doi-access = free

| bibcode = 2008CBio...18..136Z

}}

Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells. It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.{{Cite journal

| doi = 10.1016/j.cub.2007.10.019

| pmid = 17980596

| year = 2007

| last1 = Gomez-Ferreria | first1 = M.

| last2 = Rath | first2 = U.

| last3 = Buster | first3 = D.

| last4 = Chanda | first4 = S.

| last5 = Caldwell | first5 = J.

| last6 = Rines | first6 = D.

| last7 = Sharp | first7 = D.

| title = Human Cep192 is required for mitotic centrosome and spindle assembly

| volume = 17

| issue = 22

| pages = 1960–1966

| journal = Current Biology

| s2cid = 10245690

| doi-access = free

| bibcode = 2007CBio...17.1960G

}}

References

External links

{{UCSC gene info|CEP192}}
{{PDBe-KB2|Q8TEP8|Centrosomal protein of 192 kDa}}

{{cite journal |vauthors=Nagase T, Kikuno R, Nakayama M |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2000 |pmid= 10997877 |doi= 10.1093/dnares/7.4.271|display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Golsteyn RM, Mundt KE, Fry AM, Nigg EA |title=Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function |journal=J. Cell Biol. |volume=129 |issue= 6 |pages= 1617–28 |year= 1995 |pmid= 7790358 |pmc=2291169 |doi=10.1083/jcb.129.6.1617 }}
{{cite journal |vauthors=Zhu F, Lawo S, Bird A |title=The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis |journal=Curr. Biol. |volume=18 |issue= 2 |pages= 136–41 |year= 2008 |pmid= 18207742 |doi= 10.1016/j.cub.2007.12.055 |s2cid=16159409 |display-authors=etal|doi-access=free |bibcode=2008CBio...18..136Z }}
{{cite journal |vauthors=Gomez-Ferreria MA, Rath U, Buster DW |title=Human Cep192 is required for mitotic centrosome and spindle assembly |journal=Curr. Biol. |volume=17 |issue= 22 |pages= 1960–6 |year= 2007 |pmid= 17980596 |doi= 10.1016/j.cub.2007.10.019 |s2cid=10245690 |display-authors=etal|doi-access=free |bibcode=2007CBio...17.1960G }}
{{cite journal |vauthors=Mayor T, Stierhof YD, Tanaka K |title=The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 837–46 |year= 2000 |pmid= 11076968 |pmc=2169446 |doi=10.1083/jcb.151.4.837 |display-authors=etal}}
{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |pmc=1356129 |doi= 10.1101/gr.4039406 |display-authors=etal}}
{{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |pmc=311072 |doi= 10.1101/gr.GR1547R |display-authors=etal}}
{{cite journal |vauthors=Sowa ME, Bennett EJ, Gygi SP, Harper JW |title=Defining the Human Deubiquitinating Enzyme Interaction Landscape |journal=Cell |volume=138 |issue= 2 |pages= 389–403 |year= 2009 |pmid= 19615732 |pmc=2716422 |doi= 10.1016/j.cell.2009.04.042 }}
{{cite journal |vauthors=Takahashi M, Yamagiwa A, Nishimura T |title=Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex |journal=Mol. Biol. Cell |volume=13 |issue= 9 |pages= 3235–45 |year= 2002 |pmid= 12221128 |pmc=124155 |doi= 10.1091/mbc.E02-02-0112 |display-authors=etal}}
{{cite journal |vauthors=Casenghi M, Meraldi P, Weinhart U |title=Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation |journal=Dev. Cell |volume=5 |issue= 1 |pages= 113–25 |year= 2003 |pmid= 12852856 |doi=10.1016/S1534-5807(03)00193-X |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Petretti C, Savoian M, Montembault E |title=The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation |journal=EMBO Rep. |volume=7 |issue= 4 |pages= 418–24 |year= 2006 |pmid= 16462731 |pmc=1456919 |doi= 10.1038/sj.embor.7400639 |display-authors=etal}}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
{{cite journal |vauthors=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1–3 |pages= 203–8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007 |s2cid=9746088 }}

Category:Centrosome

CEP192

References

External links

Further reading