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CEP350

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.{{cite journal | vauthors = Yan X, Habedanck R, Nigg EA | title = A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring | journal = Mol Biol Cell | volume = 17 | issue = 2 | pages = 634–44 |date=Jan 2006 | pmid = 16314388 | pmc = 1356575 | doi = 10.1091/mbc.E05-08-0810 }}{{cite journal | vauthors = Patel H, Truant R, Rachubinski RA, Capone JP | title = Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350 | journal = J Cell Sci | volume = 118 | issue = Pt 1 | pages = 175–86 |date=Dec 2004 | pmid = 15615782 | doi = 10.1242/jcs.01600 | doi-access = free }}{{cite web | title = Entrez Gene: CEP350 centrosomal protein 350kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9857}}

CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.{{cite journal|last=Le Clech|first=M|title=Role of CAP350 in centriolar tubule stability and centriole assembly.|journal=PLOS ONE|date=2008|volume=3|issue=12|pages=e3855|pmid=19052644|doi=10.1371/journal.pone.0003855|pmc=2586089|bibcode=2008PLoSO...3.3855L|doi-access=free}}

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.

References

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External links

  • {{UCSC gene info|CEP350}}

Further reading

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  • {{cite journal | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
  • {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal | vauthors=Yu W, Andersson B, Worley KC |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |display-authors=etal}}
  • {{cite journal | vauthors=Seki N, Ohira M, Nagase T |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain |journal=DNA Res. |volume=4 |issue= 5 |pages= 345–9 |year= 1998 |pmid= 9455484 |doi=10.1093/dnares/4.5.345 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Makalowska I, Sood R, Faruque MU |title=Identification of six novel genes by experimental validation of GeneMachine predicted genes |journal=Gene |volume=284 |issue= 1–2 |pages= 203–13 |year= 2002 |pmid= 11891061 |doi=10.1016/S0378-1119(01)00897-6 |display-authors=etal}}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Andersen JS, Wilkinson CJ, Mayor T |title=Proteomic characterization of the human centrosome by protein correlation profiling |journal=Nature |volume=426 |issue= 6966 |pages= 570–4 |year= 2003 |pmid= 14654843 |doi= 10.1038/nature02166 |bibcode=2003Natur.426..570A |s2cid=4427303 |display-authors=etal}}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Oh JH, Yang JO, Hahn Y |title=Transcriptome analysis of human gastric cancer |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |s2cid=69278 |display-authors=etal}}
  • {{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
  • {{cite journal | vauthors=Nousiainen M, Silljé HH, Sauer G |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |bibcode=2006PNAS..103.5391N |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Hoppeler-Lebel A, Celati C, Bellett G |title=Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex |journal=J. Cell Sci. |volume=120 |issue= Pt 18 |pages= 3299–308 |year= 2007 |pmid= 17878239 |doi= 10.1242/jcs.013102 |display-authors=etal|doi-access=free }}

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{{Centrosome}}

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Category:Centrosome