CFLAR
{{Short description|Protein-coding gene in humans}}
{{Infobox_gene}}
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.{{cite journal | vauthors = Shu HB, Halpin DR, Goeddel DV | title = Casper is a FADD- and caspase-related inducer of apoptosis | journal = Immunity | volume = 6 | issue = 6 | pages = 751–63 |date=Jul 1997 | pmid = 9208847 | doi =10.1016/S1074-7613(00)80450-1 | doi-access = free }}{{cite journal | vauthors = Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J | title = Inhibition of death receptor signals by cellular FLIP | journal = Nature | volume = 388 | issue = 6638 | pages = 190–5 |date=Jul 1997 | pmid = 9217161 | doi = 10.1038/40657 | s2cid = 4341495 | url = https://serval.unil.ch/resource/serval:BIB_B780D8F4383C.P001/REF.pdf | doi-access = free }} Also called c-FLIP (FLICE-like inhibitory protein).
References
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Further reading
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- {{cite journal | vauthors=Abe K, Kurakin A, Mohseni-Maybodi M |title=The complexity of TNF-related apoptosis-inducing ligand. |journal=Ann. N. Y. Acad. Sci. |volume=926 |issue= 1|pages= 52–63 |year= 2001 |pmid= 11193041 |doi=10.1111/j.1749-6632.2000.tb05598.x |s2cid=45991330 |display-authors=etal}}
- {{cite journal | vauthors=Dutton A, Young LS, Murray PG |title=The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer. |journal=Expert Opin. Ther. Targets |volume=10 |issue= 1 |pages= 27–35 |year= 2006 |pmid= 16441226 |doi= 10.1517/14728222.10.1.27 |s2cid=45292123 }}
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External links
- {{UCSC gene info|CFLAR}}
- {{PDBe-KB2|O15519|CASP8 and FADD-like apoptosis regulator}}
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